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ERCC6 and PPIA
Data Source:
BioGRID
(pull down)
ERCC6
PPIA
Description
ERCC excision repair 6, chromatin remodeling factor
peptidylprolyl isomerase A
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Transcription Elongation Factor Complex
Site Of DNA Damage
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Focal Adhesion
Membrane
Vesicle
Protein-containing Complex
Secretory Granule Lumen
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
DNA Binding
DNA Helicase Activity
Chromatin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Protein Tyrosine Kinase Activator Activity
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein N-terminus Binding
RNA Binding
Peptidyl-prolyl Cis-trans Isomerase Activity
Integrin Binding
Protein Binding
Cyclosporin A Binding
Virion Binding
Unfolded Protein Binding
Heparan Sulfate Binding
Biological Process
Single Strand Break Repair
DNA Damage Checkpoint
Response To Superoxide
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Pyrimidine Dimer Repair
Transcription Elongation From RNA Polymerase I Promoter
Transcription By RNA Polymerase II
Response To Oxidative Stress
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Response To X-ray
Response To UV-B
Response To Gamma Radiation
Neurogenesis
Neuron Differentiation
Neuron Projection Development
DNA Duplex Unwinding
Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Multicellular Organism Growth
ATP-dependent Chromatin Remodeling
Photoreceptor Cell Maintenance
Positive Regulation Of DNA Repair
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Protein Tyrosine Kinase Activity
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Activation Of MAPK Activity
Protein Peptidyl-prolyl Isomerization
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
RNA-dependent DNA Biosynthetic Process
Protein Folding
Negative Regulation Of Protein Kinase Activity
Apoptotic Process
Viral Life Cycle
Uncoating Of Virus
Fusion Of Virus Membrane With Host Plasma Membrane
Virion Assembly
Viral Release From Host Cell
Platelet Activation
Neutrophil Chemotaxis
Leukocyte Chemotaxis
Activation Of Protein Kinase B Activity
Negative Regulation Of Stress-activated MAPK Cascade
Lipid Droplet Organization
Cellular Response To Oxidative Stress
Positive Regulation Of Protein Dephosphorylation
Interleukin-12-mediated Signaling Pathway
Endothelial Cell Activation
Neutrophil Degranulation
Regulation Of Viral Genome Replication
Positive Regulation Of Viral Genome Replication
Positive Regulation Of Protein Secretion
Leukocyte Migration
Positive Regulation Of NF-kappaB Transcription Factor Activity
Cell Adhesion Molecule Production
Negative Regulation Of Protein K48-linked Ubiquitination
Platelet Aggregation
Establishment Of Integrated Proviral Latency
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Viral Life Cycle
Regulation Of Apoptotic Signaling Pathway
Pathways
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
B-WICH complex positively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
RNA Polymerase I Transcription Initiation
Platelet degranulation
Uncoating of the HIV Virion
Budding and maturation of HIV virion
Integration of provirus
Early Phase of HIV Life Cycle
Minus-strand DNA synthesis
Plus-strand DNA synthesis
Binding and entry of HIV virion
Assembly Of The HIV Virion
APOBEC3G mediated resistance to HIV-1 infection
Calcineurin activates NFAT
Basigin interactions
Neutrophil degranulation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Cyclosporine
Proline
(3r)-1-Acetyl-3-Methylpiperidine
Ethyl Oxo(Piperidin-1-Yl)Acetate
Sanglifehrin A
Copper
Artenimol
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Cockayne syndrome
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Mean reticulocyte volume (
32888494
)
Red blood cell count (
32888494
)
Interacting Genes
118 interacting genes:
ACTR2
ACTR3
ARPC1A
ATP5F1C
ATP5PO
BRCA1
CAVIN1
CCT5
CCT6A
CHEK2
CLIC4
COPE
CORO1C
CSNK2A2
CSNK2B
CTSB
CUL5
DARS1
ECHS1
EIF3C
EIF3D
EIF3F
EIF3I
EIF3L
EIF4A3
ELOA
ERCC5
ERCC8
FBLN2
FNDC3B
FOSL1
FXR1
FYTTD1
GATAD2B
GRPEL1
GTF2E2
GTF2I
H2BC3
H3C1
H4C1
HDAC1
HDAC2
HNRNPUL2
HSPA5
HSPA9
HTATSF1
IARS2
IDH3G
IWS1
LEO1
MBD3
MORC3
MRPL11
MRPL13
MRPL20
MRPL21
MRPL3
MRPL38
MRPL4
MRPL47
MRPL50
MRPL58
MRPS18B
MRPS22
MRPS25
MRPS26
MTA1
MTA2
MTA3
NAP1L1
NONO
NPLOC4
PAF1
PARP1
PCNA
PFN2
PML
POLR2A
POLR2H
PPIA
PSMC5
RBBP4
RBBP7
RCC1
RHOG
RNF11
RPL10
RPL13
RPL30
RPL39
RPL5
RPS15
RPS15A
RPS24
RPS29
RPS6
SAE1
SDHA
SENP2
SF3B3
SLC39A7
SNRPD1
SUMO1
SUMO2
SUPT6H
TACO1
TP53
TPR
UBA2
UBC
UBE2I
UQCRC1
UQCRQ
USP7
XAB2
XPA
XRCC5
ZBTB38
27 interacting genes:
APP
BSG
CD99
ERCC6
ERRFI1
G3BP1
ITK
JAK2
LIG4
LNX1
N4BP2L2
NOTCH3
PAXIP1
PRLR
PRR13
PRSS23
PTPRN
RB1
S100A8
SRPK1
SRPK2
SUPT5H
TCF4
TERT
USP4
WBP4
YY1
Entrez ID
2074
5478
HPRD ID
00596
00457
Ensembl ID
ENSG00000225830
ENSG00000196262
Uniprot IDs
A8K4Q3
P0DP91
Q03468
Q59FF6
P62937
V9HWF5
PDB IDs
4CVO
6A6I
1AK4
1AWQ
1AWR
1AWS
1AWT
1AWU
1AWV
1BCK
1CWA
1CWB
1CWC
1CWF
1CWH
1CWI
1CWJ
1CWK
1CWL
1CWM
1CWO
1FGL
1M63
1M9C
1M9D
1M9E
1M9F
1M9X
1M9Y
1MF8
1MIK
1NMK
1OCA
1RMH
1VBS
1VBT
1W8L
1W8M
1W8V
1YND
1ZKF
2ALF
2CPL
2CYH
2MS4
2MZU
2N0T
2RMA
2RMB
2X25
2X2A
2X2C
2X2D
2XGY
3CYH
3CYS
3K0M
3K0N
3K0O
3K0P
3K0Q
3K0R
3ODI
3ODL
3RDD
4CYH
4IPZ
4N1M
4N1N
4N1O
4N1P
4N1Q
4N1R
4N1S
4YUG
4YUH
4YUI
4YUJ
4YUK
4YUL
4YUM
4YUN
4YUO
4YUP
5CYH
5F66
5FJB
5KUL
5KUN
5KUO
5KUQ
5KUR
5KUS
5KUU
5KUV
5KUW
5KUZ
5KV0
5KV1
5KV2
5KV3
5KV4
5KV5
5KV6
5KV7
5LUD
5NOQ
5NOR
5NOS
5NOT
5NOU
5NOV
5NOW
5NOX
5NOY
5NOZ
5T9U
5T9W
5T9Z
5TA2
5TA4
5WC7
6BTA
6GJI
6GJJ
6GJL
6GJM
6GJN
6GJP
6GJR
6GJY
6GS6
6I42
6U5C
6U5D
6U5E
6U5G
6X3R
6X3Y
6X4M
6X4N
6X4O
6X4P
6X4Q
6Y9V
6Y9W
6Y9X
6Y9Y
6Y9Z
6ZDJ
Enriched GO Terms of Interacting Partners
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