MTA2 and MED30

Data Source:
BioGRID (two hybrid)

		MTA2	MED30
Description		metastasis associated 1 family member 2	mediator complex subunit 30
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Mediator Complex
	Molecular Function	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator	Transcription Initiation From RNA Polymerase II Promoter Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS	PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Common carotid intima-media thickness ( 29206233) Common carotid intima-media thickness in HIV infection ( 29206233) Dimensional psychopathology (Arousal) ( 29496196) Facial attractiveness (female raters) ( 30946739) Fasting blood glucose ( 29212154) Kawasaki disease ( 22446961) Leprosy ( 27976721) Midgestational total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Urate levels in obese individuals ( 25811787) Vestibular neuritis ( 30079052)
Interacting Genes		23 interacting genes: APPL1 APPL2 BCL11B ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1	17 interacting genes: APP DOCK8 HGS IFT20 KRTAP10-9 MED17 MED22 MED27 MED28 MED4 MED8 MED9 MTA2 NAP1L2 NME7 PCBD2 SS18L1
Entrez ID		9219	90390
HPRD ID		07233	11631
Ensembl ID		ENSG00000149480	ENSG00000164758
Uniprot IDs		A0A024R534 O94776	Q96HR3
PDB IDs
Enriched GO Terms of Interacting Partners?
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