Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
ERCC6 and CSNK2A2
Data Source:
BioGRID
(pull down)
ERCC6
CSNK2A2
Description
ERCC excision repair 6, chromatin remodeling factor
casein kinase 2 alpha 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Transcription Elongation Factor Complex
Site Of DNA Damage
Chromatin
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytosol
Plasma Membrane
Protein Kinase CK2 Complex
PcG Protein Complex
Molecular Function
DNA Binding
DNA Helicase Activity
Chromatin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Protein Tyrosine Kinase Activator Activity
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein N-terminus Binding
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Protein N-terminus Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Single Strand Break Repair
DNA Damage Checkpoint
Response To Superoxide
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Pyrimidine Dimer Repair
Transcription Elongation From RNA Polymerase I Promoter
Transcription By RNA Polymerase II
Response To Oxidative Stress
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Response To X-ray
Response To UV-B
Response To Gamma Radiation
Neurogenesis
Neuron Differentiation
Neuron Projection Development
DNA Duplex Unwinding
Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Multicellular Organism Growth
ATP-dependent Chromatin Remodeling
Photoreceptor Cell Maintenance
Positive Regulation Of DNA Repair
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Protein Tyrosine Kinase Activity
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Protein Folding
Phosphatidylcholine Biosynthetic Process
Apoptotic Process
Cell Cycle
Spermatogenesis
Wnt Signaling Pathway
Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cerebral Cortex Development
Regulation Of Cell Cycle
Liver Regeneration
Regulation Of Signal Transduction By P53 Class Mediator
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Regulation Of Chromosome Separation
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Apoptotic Signaling Pathway
Pathways
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
B-WICH complex positively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
RNA Polymerase I Transcription Initiation
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity
Drugs
[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid
Fostamatinib
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Cockayne syndrome
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Primary biliary cholangitis (
28425483
)
Rosacea symptom severity (
29771307
)
Systemic lupus erythematosus (
28714469
)
Telomere length (
24795349
)
Interacting Genes
118 interacting genes:
ACTR2
ACTR3
ARPC1A
ATP5F1C
ATP5PO
BRCA1
CAVIN1
CCT5
CCT6A
CHEK2
CLIC4
COPE
CORO1C
CSNK2A2
CSNK2B
CTSB
CUL5
DARS1
ECHS1
EIF3C
EIF3D
EIF3F
EIF3I
EIF3L
EIF4A3
ELOA
ERCC5
ERCC8
FBLN2
FNDC3B
FOSL1
FXR1
FYTTD1
GATAD2B
GRPEL1
GTF2E2
GTF2I
H2BC3
H3C1
H4C1
HDAC1
HDAC2
HNRNPUL2
HSPA5
HSPA9
HTATSF1
IARS2
IDH3G
IWS1
LEO1
MBD3
MORC3
MRPL11
MRPL13
MRPL20
MRPL21
MRPL3
MRPL38
MRPL4
MRPL47
MRPL50
MRPL58
MRPS18B
MRPS22
MRPS25
MRPS26
MTA1
MTA2
MTA3
NAP1L1
NONO
NPLOC4
PAF1
PARP1
PCNA
PFN2
PML
POLR2A
POLR2H
PPIA
PSMC5
RBBP4
RBBP7
RCC1
RHOG
RNF11
RPL10
RPL13
RPL30
RPL39
RPL5
RPS15
RPS15A
RPS24
RPS29
RPS6
SAE1
SDHA
SENP2
SF3B3
SLC39A7
SNRPD1
SUMO1
SUMO2
SUPT6H
TACO1
TP53
TPR
UBA2
UBC
UBE2I
UQCRC1
UQCRQ
USP7
XAB2
XPA
XRCC5
ZBTB38
102 interacting genes:
ABCA1
ACACA
ADH1A
AQP4
ARRB2
ASL
ATF1
ATF2
ATG16L1
BHLHE41
BID
CABP1
CALM1
CASQ2
CAV1
CDC37
CLTB
CREBBP
CREM
CSN3
CSNK2B
CTDP1
DCPS
DELEC1
EEF1B2
EIF2B2
EIF2B5
EIF4EBP1
ERCC6
ERH
FGF1
FGF2
FKBP3
FOS
GTF2A1
GTF2A1L
H1-2
HDAC1
HDAC2
HDAC6
HMGA1
HMGA2
HNRNPC
HSP90AA1
HSP90B1
HSPH1
IL16
KDM1A
KIF1C
KLF1
LAMC3
LGALS3
MAF1
MAPK14
MDM2
MGMT
MS4A1
MYC
MYCN
MYF5
NAP1L4
NCL
NR1D2
P4HB
PAK1
PICK1
PIN1
PIN4
PPP1R1B
PPP1R2
PPP1R8
PRNP
PTEN
PTPN1
PTPRC
RAD1
RAD9A
RELA
RGS19
SAT1
SLC18A2
SMURF1
SNCA
SNX6
SPIB
SPP1
STX1A
TCF7L2
TCOF1
TGFBR1
TGM2
TOP1
TP53
TP63
TRIM41
TTLL12
UBE2R2
WAS
XRCC1
ZNF219
ZNF670
ZNHIT3
Entrez ID
2074
1459
HPRD ID
00596
00279
Ensembl ID
ENSG00000225830
ENSG00000070770
Uniprot IDs
A8K4Q3
P0DP91
Q03468
Q59FF6
P19784
PDB IDs
4CVO
6A6I
3E3B
3OFM
3U87
5M4U
5M56
5OOI
5Y9M
5YF9
5YWM
6HMB
6HMC
6HMD
6HMQ
6L20
6QY8
6QY9
6TE2
6TEW
6TGU
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?