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MTA2 and APPL1
Data Source:
HPRD
(in vivo, in vitro)
MTA2
APPL1
Description
metastasis associated 1 family member 2
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Image
No pdb structure
GO Annotations
Cellular Component
Histone Deacetylase Complex
Chromatin
Nucleoplasm
Transcription Regulator Complex
Membrane
NuRD Complex
Protein-containing Complex
Ruffle
Nucleus
Cytoplasm
Endosome
Early Endosome
Cytosol
Plasma Membrane
Endosome Membrane
Vesicle Membrane
Membrane
Cytoplasmic Vesicle
Early Endosome Membrane
Early Phagosome
Macropinosome
Extracellular Exosome
Intracellular Vesicle
Molecular Function
RNA Polymerase II Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
Histone Deacetylase Activity
Protein Binding
Zinc Ion Binding
Nucleosomal DNA Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Phosphatidylserine Binding
Protein Binding
Phosphatidylinositol Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Kinase B Binding
Protein-containing Complex Binding
Beta-tubulin Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
DNA Methylation
Chromatin Assembly Or Disassembly
Regulation Of Fibroblast Migration
Histone Deacetylation
ATP-dependent Chromatin Remodeling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Signal Transduction By P53 Class Mediator
Protein Import Into Nucleus
Cell Cycle
Signal Transduction
Transforming Growth Factor Beta Receptor Signaling Pathway
Insulin Receptor Signaling Pathway
Regulation Of Fibroblast Migration
Signaling
Adiponectin-activated Signaling Pathway
Regulation Of Toll-like Receptor 4 Signaling Pathway
Cellular Response To Hepatocyte Growth Factor Stimulus
Regulation Of Innate Immune Response
Regulation Of Glucose Import
Positive Regulation Of Glucose Import
Positive Regulation Of Melanin Biosynthetic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Macropinocytosis
Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
HDACs deacetylate histones
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Regulation of TP53 Activity through Acetylation
RNA Polymerase I Transcription Initiation
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Potential therapeutics for SARS
Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases
GWAS
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
23 interacting genes:
APPL1
APPL2
BCL11B
ERCC6
ESR1
FKBP3
H3-4
HNRNPD
MBD3
MBD3L2
MED30
NACC2
RBBP4
RBBP7
SATB1
SATB2
SPEN
SUMO2
TP53
TSC22D3
UBE3C
USP11
YY1
64 interacting genes:
ADI1
ADIPOR1
ADIPOR2
AGL
AKT1
AKT2
ANKRD1
APPL2
ATP2A1
BATF3
BIN1
BRWD1
C1QTNF9
CBL
CBLB
CIPC
CMTM4
CTTNBP2
DACT1
DCC
DNM2
DOK2
DOK3
DOK7
DPYSL5
DTNA
DYSF
EGFR
FARS2
FSHR
GPC3
HDAC2
HSPB1
ID1
INO80E
KLF15
KXD1
LUC7L
MAGEA9
MAGEC3
MAP3K1
MEOX1
MTA2
MYCBP2
MYH3
PIK3CA
PIK3R1
PIK3R2
PLEKHF2
PNMA5
RAB21
RAB5A
RBBP7
RHEBL1
RUVBL2
SCAPER
SH2D2A
SOCS6
SPART
TP53
TP53BP2
TRAF2
UBE2O
ZNF829
Entrez ID
9219
26060
HPRD ID
07233
05053
Ensembl ID
ENSG00000149480
ENSG00000157500
Uniprot IDs
A0A024R534
O94776
Q9UKG1
PDB IDs
2EJ8
2ELA
2ELB
2Q12
2Q13
2Z0N
2Z0O
5C5B
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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