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ERCC6 and HSPA9
Data Source:
BioGRID
(pull down)
ERCC6
HSPA9
Description
ERCC excision repair 6, chromatin remodeling factor
heat shock protein family A (Hsp70) member 9
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Transcription Elongation Factor Complex
Site Of DNA Damage
SAM Complex
Nucleolus
Cytoplasm
Mitochondrion
Mitochondrial Matrix
Focal Adhesion
Mitochondrial Nucleoid
Extracellular Exosome
MIB Complex
Molecular Function
DNA Binding
DNA Helicase Activity
Chromatin Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
DNA-dependent ATPase Activity
Protein Tyrosine Kinase Activator Activity
Sequence-specific DNA Binding
Protein-containing Complex Binding
Protein N-terminus Binding
RNA Binding
Protein Binding
ATP Binding
ATPase Activity
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Protein Folding Chaperone
Unfolded Protein Binding
Misfolded Protein Binding
Biological Process
Single Strand Break Repair
DNA Damage Checkpoint
Response To Superoxide
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Pyrimidine Dimer Repair
Transcription Elongation From RNA Polymerase I Promoter
Transcription By RNA Polymerase II
Response To Oxidative Stress
Activation Of JNKK Activity
Activation Of JUN Kinase Activity
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To UV
Response To Toxic Substance
Response To X-ray
Response To UV-B
Response To Gamma Radiation
Neurogenesis
Neuron Differentiation
Neuron Projection Development
DNA Duplex Unwinding
Regulation Of DNA-templated Transcription, Elongation
Positive Regulation Of DNA-templated Transcription, Elongation
Multicellular Organism Growth
ATP-dependent Chromatin Remodeling
Photoreceptor Cell Maintenance
Positive Regulation Of DNA Repair
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Positive Regulation Of Protein Tyrosine Kinase Activity
Double-strand Break Repair Via Classical Nonhomologous End Joining
Positive Regulation Of Double-strand Break Repair Via Homologous Recombination
Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Protein Export From Nucleus
Inner Mitochondrial Membrane Organization
Iron-sulfur Cluster Assembly
Erythrocyte Differentiation
Cellular Response To Unfolded Protein
Interleukin-12-mediated Signaling Pathway
Protein Refolding
Negative Regulation Of Apoptotic Process
Regulation Of Erythrocyte Differentiation
Negative Regulation Of Erythrocyte Differentiation
Chaperone Cofactor-dependent Protein Refolding
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Hemopoiesis
Pathways
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
B-WICH complex positively regulates rRNA expression
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
RNA Polymerase I Transcription Initiation
Mitochondrial protein import
Regulation of HSF1-mediated heat shock response
Cristae formation
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases
Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
Cockayne syndrome
Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
GWAS
Pulse pressure x alcohol consumption interaction (2df test) (
29912962
)
Autism spectrum disorder or schizophrenia (
28540026
)
Cerebrospinal AB1-42 levels in Alzheimer's disease dementia (
29274321
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
118 interacting genes:
ACTR2
ACTR3
ARPC1A
ATP5F1C
ATP5PO
BRCA1
CAVIN1
CCT5
CCT6A
CHEK2
CLIC4
COPE
CORO1C
CSNK2A2
CSNK2B
CTSB
CUL5
DARS1
ECHS1
EIF3C
EIF3D
EIF3F
EIF3I
EIF3L
EIF4A3
ELOA
ERCC5
ERCC8
FBLN2
FNDC3B
FOSL1
FXR1
FYTTD1
GATAD2B
GRPEL1
GTF2E2
GTF2I
H2BC3
H3C1
H4C1
HDAC1
HDAC2
HNRNPUL2
HSPA5
HSPA9
HTATSF1
IARS2
IDH3G
IWS1
LEO1
MBD3
MORC3
MRPL11
MRPL13
MRPL20
MRPL21
MRPL3
MRPL38
MRPL4
MRPL47
MRPL50
MRPL58
MRPS18B
MRPS22
MRPS25
MRPS26
MTA1
MTA2
MTA3
NAP1L1
NONO
NPLOC4
PAF1
PARP1
PCNA
PFN2
PML
POLR2A
POLR2H
PPIA
PSMC5
RBBP4
RBBP7
RCC1
RHOG
RNF11
RPL10
RPL13
RPL30
RPL39
RPL5
RPS15
RPS15A
RPS24
RPS29
RPS6
SAE1
SDHA
SENP2
SF3B3
SLC39A7
SNRPD1
SUMO1
SUMO2
SUPT6H
TACO1
TP53
TPR
UBA2
UBC
UBE2I
UQCRC1
UQCRQ
USP7
XAB2
XPA
XRCC5
ZBTB38
26 interacting genes:
APP
DNAJC19
DNLZ
ERBB2
ERCC6
FGF1
HSP90B1
HSPBP1
LAMTOR5
LINC01554
LSM8
MATK
MVD
NELFB
PTPN11
PTPRF
SIRPA
STUB1
SUMO2
SUMO4
SUPT6H
TIMM44
TP53
XPO1
YKT6
YWHAG
Entrez ID
2074
3313
HPRD ID
00596
02770
Ensembl ID
ENSG00000225830
ENSG00000113013
Uniprot IDs
A8K4Q3
P0DP91
Q03468
Q59FF6
A0A384P5G6
P38646
PDB IDs
4CVO
6A6I
3N8E
4KBO
6NHK
6P2U
6PMT
Enriched GO Terms of Interacting Partners
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