MTA2 and NACC2

Data Source:
BioGRID (pull down)

		MTA2	NACC2
Description		metastasis associated 1 family member 2	NACC family member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleoplasm Transcription Regulator Complex Membrane NuRD Complex Protein-containing Complex	Chromatin Nucleus Nucleolus Mitochondrion
	Molecular Function	RNA Polymerase II Transcription Factor Binding RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Activity Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding Nucleosomal DNA Binding Histone Deacetylase Binding Sequence-specific DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Chromatin Assembly Or Disassembly Regulation Of Fibroblast Migration Histone Deacetylation ATP-dependent Chromatin Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Population Proliferation Cellular Protein-containing Complex Localization Negative Regulation Of Transcription, DNA-templated Protein Homooligomerization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle By Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		HDACs deacetylate histones ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) SjÃ¶gren's syndrome ( 28076899) Ulcerative colitis ( 28067908)
Interacting Genes		23 interacting genes: APPL1 APPL2 BCL11B ERCC6 ESR1 FKBP3 H3-4 HNRNPD MBD3 MBD3L2 MED30 NACC2 RBBP4 RBBP7 SATB1 SATB2 SPEN SUMO2 TP53 TSC22D3 UBE3C USP11 YY1	5 interacting genes: EPS8 HDAC2 MTA1 MTA2 MTA3
Entrez ID		9219	138151
HPRD ID		07233	09831
Ensembl ID		ENSG00000149480	ENSG00000148411
Uniprot IDs		A0A024R534 O94776	A0A024R8I0 Q96BF6
PDB IDs
Enriched GO Terms of Interacting Partners?
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