BCL10 and OTULIN

Data Source:
BioGRID (enzymatic study)

		BCL10	OTULIN
Description		BCL10 immune signaling adaptor	OTU deubiquitinase with linear linkage specificity
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GO Annotations	Cellular Component	Immunological Synapse Polkadots Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol LUBAC Complex
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Kinase Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Kinase B Binding Protein Self-association Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity
	Biological Process	B Cell Apoptotic Process Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Adaptive Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Cellular Defense Response I-kappaB Kinase/NF-kappaB Signaling Cell Death Response To Fungus Immunoglobulin Mediated Immune Response Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Sprouting Angiogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Protein Phosphopantetheinylation Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins	Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)	Asthma ( 31959851 31619474) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058)
Interacting Genes		46 interacting genes: AKT1 ANP32B ATM BAAT BIRC3 CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SLC9A3R1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1	11 interacting genes: BCL10 DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239 UBE2D1
Entrez ID		8915	90268
HPRD ID		04625	14266
Ensembl ID		ENSG00000142867	ENSG00000154124
Uniprot IDs		A0A087WWW9 A2TDT2 O95999	Q96BN8
PDB IDs		2MB9 6BZE 6GK2	3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK
Enriched GO Terms of Interacting Partners?
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