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BCL10 and ANP32B
Data Source:
BioGRID
(two hybrid)
BCL10
ANP32B
Description
BCL10 immune signaling adaptor
acidic nuclear phosphoprotein 32 family member B
Image
GO Annotations
Cellular Component
Immunological Synapse
Polkadots
Nucleus
Cytoplasm
Lysosome
Cytosol
Cytoplasmic Microtubule
CBM Complex
Protein-containing Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Extracellular Exosome
Molecular Function
Protease Binding
Transcription Coactivator Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Kinase Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Kinase B Binding
Protein Self-association
Protein-containing Complex Binding
CARD Domain Binding
NF-kappaB Binding
Protein Binding
Histone Binding
RNA Polymerase Binding
Biological Process
B Cell Apoptotic Process
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Cellular Defense Response
I-kappaB Kinase/NF-kappaB Signaling
Cell Death
Response To Fungus
Immunoglobulin Mediated Immune Response
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Response To Food
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Lymphotoxin A Production
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
T Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
T Cell Apoptotic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Vasculature Development
Nucleosome Assembly
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Ventricular System Development
Regulation Of Apoptotic Process
Negative Regulation Of Cell Differentiation
Positive Regulation Of Protein Export From Nucleus
Inner Ear Development
Roof Of Mouth Development
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Multiple sclerosis (
24076602
)
Alopecia areata (
25608926
)
Coronary artery disease (
29212778
)
Eosinophil counts (
32888494
)
Immature fraction of reticulocytes (
27863252
)
Mean corpuscular hemoglobin (
32888494
27863252
)
Mean corpuscular volume (
32888494
)
Red blood cell count (
32888494
27863252
)
Serum thyroid-stimulating hormone levels (
25436638
)
Interacting Genes
46 interacting genes:
AKT1
ANP32B
ATM
BAAT
BIRC3
CARD10
CARD11
CARD14
CARD19
CARD9
CASP9
CCDC180
CDC14B
CDK9
CHUK
COG6
FBP1
HEMGN
IKBKG
IL15RA
IRAK1
MALT1
MAP3K7
MIB2
NANS
NLRC4
OTULIN
PELI2
PRRG4
RASA1
RIPK2
RNF181
SLC20A1
SLC9A3R1
SOCS3
SRSF1
TGFB1
TLR4
TNFRSF10A
TNFRSF1A
TRADD
TRAF2
TRMO
UBE2N
UBE2V2
USHBP1
43 interacting genes:
AIM2
APC
APP
AURKA
BAX
BCL10
BEND7
BUB1
CHAF1A
CSNK2A1
DCC
DNTTIP1
ELAVL1
ESR1
FAM217B
FAM3A
FBXW7
H2AC1
H2BC1
H3C1
H4C1
HNF4A
KLF5
KPNA1
KPNA5
KPNA6
MCC
MEOX2
MLH3
MYNN
PMS2
POLR1A
PTEN
PTPN12
PTPRJ
SDCBP
SMAD2
SMARCD1
STK11
TLR2
UCHL5
XPO1
YAF2
Entrez ID
8915
10541
HPRD ID
04625
09803
Ensembl ID
ENSG00000142867
ENSG00000136938
Uniprot IDs
A0A087WWW9
A2TDT2
O95999
Q92688
PDB IDs
2MB9
6BZE
6GK2
2ELL
2RR6
Enriched GO Terms of Interacting Partners
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