BCL10 and CARD11

Data Source:
HPRD (in vivo, in vitro)

		BCL10	CARD11
Description		BCL10 immune signaling adaptor	caspase recruitment domain family member 11
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GO Annotations	Cellular Component	Immunological Synapse Polkadots Nucleus Cytoplasm Lysosome Cytosol Cytoplasmic Microtubule CBM Complex Protein-containing Complex Membrane Raft Perinuclear Region Of Cytoplasm	Immunological Synapse Cytoplasm Cytosol Plasma Membrane CBM Complex Membrane Raft Extracellular Exosome
	Molecular Function	Protease Binding Transcription Coactivator Activity Protein Binding Protein C-terminus Binding Transcription Factor Binding Kinase Activator Activity Enzyme Binding Kinase Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Kinase B Binding Protein Self-association Protein-containing Complex Binding CARD Domain Binding NF-kappaB Binding	Guanylate Kinase Activity Protein Binding CARD Domain Binding
	Biological Process	B Cell Apoptotic Process Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Adaptive Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Cellular Defense Response I-kappaB Kinase/NF-kappaB Signaling Cell Death Response To Fungus Immunoglobulin Mediated Immune Response Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Response To Food Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Lymphotoxin A Production Positive Regulation Of Mast Cell Cytokine Production Positive Regulation Of Kinase Activity Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated T Cell Receptor Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity T Cell Apoptotic Process Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Stimulatory C-type Lectin Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway TORC1 Signaling B Cell Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process GDP Metabolic Process Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Multiple sclerosis ( 24076602)	Atopic dermatitis ( 23042114) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Dupuytren's disease ( 28886342) Intracranial aneurysm ( 29531279) Multiple sclerosis ( 31604244 24076602) Response to fenofibrate (total cholesterol levels) ( 27002377) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)
Interacting Genes		46 interacting genes: AKT1 ANP32B ATM BAAT BIRC3 CARD10 CARD11 CARD14 CARD19 CARD9 CASP9 CCDC180 CDC14B CDK9 CHUK COG6 FBP1 HEMGN IKBKG IL15RA IRAK1 MALT1 MAP3K7 MIB2 NANS NLRC4 OTULIN PELI2 PRRG4 RASA1 RIPK2 RNF181 SLC20A1 SLC9A3R1 SOCS3 SRSF1 TGFB1 TLR4 TNFRSF10A TNFRSF1A TRADD TRAF2 TRMO UBE2N UBE2V2 USHBP1	15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70
Entrez ID		8915	84433
HPRD ID		04625	06234
Ensembl ID		ENSG00000142867	ENSG00000198286
Uniprot IDs		A0A087WWW9 A2TDT2 O95999	A0A024R854 Q8TES3 Q9BXL7
PDB IDs		2MB9 6BZE 6GK2	4JUP 4LWD
Enriched GO Terms of Interacting Partners?
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