OTULIN and OTUD7B

Data Source:
BioGRID (two hybrid)

		OTULIN	OTUD7B
Description		OTU deubiquitinase with linear linkage specificity	OTU deubiquitinase 7B
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GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex	Nucleus Cytoplasm Cytosol
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity	DNA Binding Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity Zinc Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Sprouting Angiogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Protein Phosphopantetheinylation Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Adaptive Immune Response Mucosal Immune Response Protein Deubiquitination Protein Phosphopantetheinylation Negative Regulation Of Interleukin-8 Production Protein K11-linked Deubiquitination Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Protein Deubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Localization To Nucleus
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Asthma ( 31959851 31619474) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Heel bone mineral density ( 30598549) Height ( 25282103) Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 32154731)
Interacting Genes		11 interacting genes: BCL10 DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239 UBE2D1	18 interacting genes: AURKA CCNB1 CDC20 CDIP1 DAZAP2 EPM2AIP1 FZR1 HSFY1 HSFY2 OTULIN PPP1R32 PSMB1 SOX2 SPART TRAF6 UBC UBE2S ZDHHC17
Entrez ID		90268	56957
HPRD ID		14266	10313
Ensembl ID		ENSG00000154124	ENSG00000264522
Uniprot IDs		Q96BN8	Q6GQQ9
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK	5LRU 5LRV 5LRW
Enriched GO Terms of Interacting Partners?
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