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BCL10 and SRSF1
Data Source:
BioGRID
(two hybrid)
BCL10
SRSF1
Description
BCL10 immune signaling adaptor
serine and arginine rich splicing factor 1
Image
GO Annotations
Cellular Component
Immunological Synapse
Polkadots
Nucleus
Cytoplasm
Lysosome
Cytosol
Cytoplasmic Microtubule
CBM Complex
Protein-containing Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Speck
Exon-exon Junction Complex
Catalytic Step 2 Spliceosome
Molecular Function
Protease Binding
Transcription Coactivator Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Kinase Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Kinase B Binding
Protein Self-association
Protein-containing Complex Binding
CARD Domain Binding
NF-kappaB Binding
RNA Binding
MRNA Binding
Protein Binding
DNA Topoisomerase Binding
Biological Process
B Cell Apoptotic Process
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Cellular Defense Response
I-kappaB Kinase/NF-kappaB Signaling
Cell Death
Response To Fungus
Immunoglobulin Mediated Immune Response
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Response To Food
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Lymphotoxin A Production
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
T Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
T Cell Apoptotic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Alternative MRNA Splicing, Via Spliceosome
MRNA 5'-splice Site Recognition
MRNA Splicing, Via Spliceosome
MRNA Splice Site Selection
MRNA Processing
RNA Export From Nucleus
MRNA Export From Nucleus
MRNA 3'-end Processing
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
E3 ubiquitin ligases ubiquitinate target proteins
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Drugs
Copper
Diseases
GWAS
Metabolite levels (
23823483
)
Multiple sclerosis (
24076602
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Interacting Genes
46 interacting genes:
AKT1
ANP32B
ATM
BAAT
BIRC3
CARD10
CARD11
CARD14
CARD19
CARD9
CASP9
CCDC180
CDC14B
CDK9
CHUK
COG6
FBP1
HEMGN
IKBKG
IL15RA
IRAK1
MALT1
MAP3K7
MIB2
NANS
NLRC4
OTULIN
PELI2
PRRG4
RASA1
RIPK2
RNF181
SLC20A1
SLC9A3R1
SOCS3
SRSF1
TGFB1
TLR4
TNFRSF10A
TNFRSF1A
TRADD
TRAF2
TRMO
UBE2N
UBE2V2
USHBP1
43 interacting genes:
AKAP17A
APP
BCL10
C1QBP
CACNA1A
CD8A
CDC42
CDK12
CDK6
CLK1
DIDO1
DYRK1A
GEMIN2
HIPK3
HNRNPA0
LNX1
LUC7L3
NFYA
NXF1
PPARG
PRPF4
PRPF4B
PSIP1
RNPS1
SCAF11
SNRNP70
SREK1
SRPK1
SRPK2
SRSF10
SRSF11
SRSF4
SRSF5
TCERG1
TNPO3
TOP1
TP53
TRA2B
U2AF1
U2AF2
XBP1
YTHDC1
ZRSR2
Entrez ID
8915
6426
HPRD ID
04625
02887
Ensembl ID
ENSG00000142867
ENSG00000136450
Uniprot IDs
A0A087WWW9
A2TDT2
O95999
Q07955
Q59FA2
PDB IDs
2MB9
6BZE
6GK2
1X4A
2M7S
2M8D
2O3D
3BEG
4C0O
Enriched GO Terms of Interacting Partners
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