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BCL10 and TRADD
Data Source:
HPRD
(in vivo)
BCL10
TRADD
Description
BCL10 immune signaling adaptor
TNFRSF1A associated via death domain
Image
GO Annotations
Cellular Component
Immunological Synapse
Polkadots
Nucleus
Cytoplasm
Lysosome
Cytosol
Cytoplasmic Microtubule
CBM Complex
Protein-containing Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Tumor Necrosis Factor Receptor Superfamily Complex
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Plasma Membrane
Death-inducing Signaling Complex
Receptor Complex
Membrane Raft
Molecular Function
Protease Binding
Transcription Coactivator Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Kinase Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Kinase B Binding
Protein Self-association
Protein-containing Complex Binding
CARD Domain Binding
NF-kappaB Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Kinase Binding
Identical Protein Binding
Protein-containing Complex Binding
Death Domain Binding
Biological Process
B Cell Apoptotic Process
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Cellular Defense Response
I-kappaB Kinase/NF-kappaB Signaling
Cell Death
Response To Fungus
Immunoglobulin Mediated Immune Response
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Response To Food
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Lymphotoxin A Production
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
T Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
T Cell Apoptotic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Cell Migration
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Inflammatory Response
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Hair Follicle Development
Cellular Response To Tumor Necrosis Factor
Death-inducing Signaling Complex Assembly
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of NIK/NF-kappaB Signaling
Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
E3 ubiquitin ligases ubiquitinate target proteins
Caspase activation via Death Receptors in the presence of ligand
Regulation by c-FLIP
RIPK1-mediated regulated necrosis
CASP8 activity is inhibited
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Regulation of necroptotic cell death
Dimerization of procaspase-8
TNF signaling
Defective RIPK1-mediated regulated necrosis
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Multiple sclerosis (
24076602
)
Interacting Genes
46 interacting genes:
AKT1
ANP32B
ATM
BAAT
BIRC3
CARD10
CARD11
CARD14
CARD19
CARD9
CASP9
CCDC180
CDC14B
CDK9
CHUK
COG6
FBP1
HEMGN
IKBKG
IL15RA
IRAK1
MALT1
MAP3K7
MIB2
NANS
NLRC4
OTULIN
PELI2
PRRG4
RASA1
RIPK2
RNF181
SLC20A1
SLC9A3R1
SOCS3
SRSF1
TGFB1
TLR4
TNFRSF10A
TNFRSF1A
TRADD
TRAF2
TRMO
UBE2N
UBE2V2
USHBP1
24 interacting genes:
APBB2
BCL10
BIRC2
CNTRL
DAPK1
FADD
FAS
HIPK2
KRT14
KRT18
NGFR
PPP2R1A
RIPK1
STAT1
TMC8
TNFRSF10A
TNFRSF10B
TNFRSF1A
TNFRSF21
TNFRSF25
TRAF1
TRAF2
TRAF3
TRPC4AP
Entrez ID
8915
8717
HPRD ID
04625
04610
Ensembl ID
ENSG00000142867
ENSG00000102871
Uniprot IDs
A0A087WWW9
A2TDT2
O95999
Q15628
PDB IDs
2MB9
6BZE
6GK2
1F2H
1F3V
5XME
6AC0
Enriched GO Terms of Interacting Partners
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