Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
BCL10 and BIRC3
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
BCL10
BIRC3
Description
BCL10 immune signaling adaptor
baculoviral IAP repeat containing 3
Image
GO Annotations
Cellular Component
Immunological Synapse
Polkadots
Nucleus
Cytoplasm
Lysosome
Cytosol
Cytoplasmic Microtubule
CBM Complex
Protein-containing Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protease Binding
Transcription Coactivator Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Kinase Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Kinase B Binding
Protein Self-association
Protein-containing Complex Binding
CARD Domain Binding
NF-kappaB Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transferase Activity
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Biological Process
B Cell Apoptotic Process
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Cellular Defense Response
I-kappaB Kinase/NF-kappaB Signaling
Cell Death
Response To Fungus
Immunoglobulin Mediated Immune Response
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Response To Food
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Lymphotoxin A Production
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
T Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
T Cell Apoptotic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Apoptotic Process
Cell Surface Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Protein Ubiquitination
Protein Deubiquitination
Positive Regulation Of Protein Ubiquitination
Tumor Necrosis Factor-mediated Signaling Pathway
Regulation Of Toll-like Receptor Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Regulation Of RIG-I Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Innate Immune Response
Regulation Of Inflammatory Response
Regulation Of Cell Cycle
Regulation Of Necroptotic Process
Negative Regulation Of Necroptotic Process
Regulation Of Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of Cysteine-type Endopeptidase Activity
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
E3 ubiquitin ligases ubiquitinate target proteins
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIPK1-mediated regulated necrosis
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
TNFR2 non-canonical NF-kB pathway
Regulation of necroptotic cell death
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Ub-specific processing proteases
IKK complex recruitment mediated by RIP1
Drugs
Diseases
GWAS
Metabolite levels (
23823483
)
Multiple sclerosis (
24076602
)
Prostate cancer (
23535732
)
Whole-brain volume (Alzheimer's disease interaction) (
21116278
)
Interacting Genes
46 interacting genes:
AKT1
ANP32B
ATM
BAAT
BIRC3
CARD10
CARD11
CARD14
CARD19
CARD9
CASP9
CCDC180
CDC14B
CDK9
CHUK
COG6
FBP1
HEMGN
IKBKG
IL15RA
IRAK1
MALT1
MAP3K7
MIB2
NANS
NLRC4
OTULIN
PELI2
PRRG4
RASA1
RIPK2
RNF181
SLC20A1
SLC9A3R1
SOCS3
SRSF1
TGFB1
TLR4
TNFRSF10A
TNFRSF1A
TRADD
TRAF2
TRMO
UBE2N
UBE2V2
USHBP1
41 interacting genes:
BCL10
BIRC5
CASP3
CASP7
CASP9
CD40
CYFIP2
DIABLO
DZIP3
GLMN
GSPT1
HAX1
HTRA2
IKBKE
IKBKG
MAP3K14
MBTPS1
PACS2
PELI1
RAF1
RCHY1
RIPK1
RIPK2
RIPK3
RIPK4
SNX7
SPHK1
SUMO1
TRAF1
TRAF2
TRAF3
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2I
UBE2N
UBE2Q2
UBE2V1
USP19
YOD1
Entrez ID
8915
330
HPRD ID
04625
03426
Ensembl ID
ENSG00000142867
ENSG00000023445
Uniprot IDs
A0A087WWW9
A2TDT2
O95999
Q13489
PDB IDs
2MB9
6BZE
6GK2
2UVL
3EB5
3EB6
3M0A
3M0D
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?