OTULIN and SFT2D1

Data Source:
BioGRID (two hybrid)

		OTULIN	SFT2D1
Description		OTU deubiquitinase with linear linkage specificity	SFT2 domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol LUBAC Complex	Integral Component Of Membrane
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity	Protein Binding
	Biological Process	Sprouting Angiogenesis Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Protein Ubiquitination Protein Phosphopantetheinylation Negative Regulation Of NF-kappaB Transcription Factor Activity Innate Immune Response Negative Regulation Of Inflammatory Response Regulation Of Canonical Wnt Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Linear Deubiquitination	Protein Transport Vesicle-mediated Transport
Pathways		Regulation of TNFR1 signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Drugs
Diseases
GWAS		Asthma ( 31959851 31619474) Asthma (childhood onset) ( 31036433) Cerebrospinal fluid neurofilament light levels ( 31930058)
Interacting Genes		11 interacting genes: BCL10 DAZAP2 DVL2 FAM168A OTUD7B SFT2D1 SPART SPATA2 SUSD6 TMEM239 UBE2D1	26 interacting genes: AQP6 ARFIP1 CERCAM DERL2 DIABLO MIEF2 MYG1 OTULIN PLEKHB2 PNKP REEP4 RETREG3 SCAND1 SCN3B SDCBP SLC10A1 SLC30A8 SNX1 SPG21 STOM SYT16 TBRG4 TMEM14B TMEM255B TMEM86B TMX2
Entrez ID		90268	113402
HPRD ID		14266	12903
Ensembl ID		ENSG00000154124	ENSG00000198818
Uniprot IDs		Q96BN8	Q8WV19
PDB IDs		3ZNV 3ZNX 3ZNZ 4KSJ 4KSK 4KSL 4OYK 4P0B 5OE7 6I9C 6SAK
Enriched GO Terms of Interacting Partners?
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