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BCL10 and CASP9
Data Source:
HPRD
(in vivo)
BCL10
CASP9
Description
BCL10 immune signaling adaptor
caspase 9
Image
GO Annotations
Cellular Component
Immunological Synapse
Polkadots
Nucleus
Cytoplasm
Lysosome
Cytosol
Cytoplasmic Microtubule
CBM Complex
Protein-containing Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Cytoplasm
Cytosol
Protein-containing Complex
Apoptosome
Molecular Function
Protease Binding
Transcription Coactivator Activity
Protein Binding
Protein C-terminus Binding
Transcription Factor Binding
Kinase Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Identical Protein Binding
Protein Kinase B Binding
Protein Self-association
Protein-containing Complex Binding
CARD Domain Binding
NF-kappaB Binding
Cysteine-type Endopeptidase Activity
Protein Binding
Enzyme Activator Activity
Peptidase Activity
SH3 Domain Binding
Protein Kinase Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Biological Process
B Cell Apoptotic Process
Neural Tube Closure
Stimulatory C-type Lectin Receptor Signaling Pathway
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Negative Regulation Of Mature B Cell Apoptotic Process
Cellular Defense Response
I-kappaB Kinase/NF-kappaB Signaling
Cell Death
Response To Fungus
Immunoglobulin Mediated Immune Response
Protein Ubiquitination
Positive Regulation Of Protein Ubiquitination
Lipopolysaccharide-mediated Signaling Pathway
Response To Food
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Lymphotoxin A Production
Positive Regulation Of Mast Cell Cytokine Production
Positive Regulation Of Kinase Activity
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Phosphorylation
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
T Cell Receptor Signaling Pathway
Regulation Of T Cell Receptor Signaling Pathway
Positive Regulation Of T Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
T Cell Apoptotic Process
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Proteolysis
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C
Platelet Formation
Cellular Response To UV
Signal Transduction In Response To DNA Damage
Positive Regulation Of Apoptotic Process
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Execution Phase Of Apoptosis
Regulation Of Response To DNA Damage Stimulus
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
Downstream TCR signaling
FCERI mediated NF-kB activation
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
E3 ubiquitin ligases ubiquitinate target proteins
Formation of apoptosome
Activation of caspases through apoptosome-mediated cleavage
SMAC (DIABLO) binds to IAPs
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes
NOD1/2 Signaling Pathway
AKT phosphorylates targets in the cytosol
Caspase activation via Dependence Receptors in the absence of ligand
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of the apoptosome activity
Regulation of the apoptosome activity
Drugs
Pamidronic acid
Diseases
GWAS
Metabolite levels (
23823483
)
Multiple sclerosis (
24076602
)
Alcoholic chronic pancreatitis (
28754779
)
Estimated glomerular filtration rate (
30604766
)
Glomerular filtration rate (creatinine) (
28452372
26831199
)
Glomerular filtration rate in non diabetics (creatinine) (
26831199
)
Urate levels (
31578528
)
Urinary metabolite levels in chronic kidney disease (
31959995
)
Interacting Genes
46 interacting genes:
AKT1
ANP32B
ATM
BAAT
BIRC3
CARD10
CARD11
CARD14
CARD19
CARD9
CASP9
CCDC180
CDC14B
CDK9
CHUK
COG6
FBP1
HEMGN
IKBKG
IL15RA
IRAK1
MALT1
MAP3K7
MIB2
NANS
NLRC4
OTULIN
PELI2
PRRG4
RASA1
RIPK2
RNF181
SLC20A1
SLC9A3R1
SOCS3
SRSF1
TGFB1
TLR4
TNFRSF10A
TNFRSF1A
TRADD
TRAF2
TRMO
UBE2N
UBE2V2
USHBP1
47 interacting genes:
ABL1
AKT1
APAF1
ARNT
BCL10
BCL2L1
BIRC2
BIRC3
BIRC5
BIRC6
BIRC7
BIRC8
CAPN2
CARD8
CASP10
CASP12
CASP3
CASP7
CASP8
CYCS
DCC
DIABLO
DSP
GMEB1
GZMB
HECTD3
HIP1
HSD17B4
HSPD1
ILK
JUN
LYN
MAP2K1
MAP2K2
MAPK1
MAPK3
MSTO1
MZB1
NAIP
NLRP1
NOD1
PRKCZ
RB1
RNF2
SRF
VIM
XIAP
Entrez ID
8915
842
HPRD ID
04625
03756
Ensembl ID
ENSG00000142867
ENSG00000132906
Uniprot IDs
A0A087WWW9
A2TDT2
O95999
F8VVS7
P55211
PDB IDs
2MB9
6BZE
6GK2
1JXQ
1NW9
2AR9
3D9T
3V3K
3YGS
4RHW
5JUY
5WVC
5WVE
Enriched GO Terms of Interacting Partners
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