LIG3 and JTB

Data Source:
HPRD (in vivo)

		LIG3	JTB
Description		DNA ligase 3	jumping translocation breakpoint
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion DNA Ligase III-XRCC1 Complex	Cytoplasm Mitochondrion Centrosome Spindle Integral Component Of Plasma Membrane Membrane Midbody
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding	Protein Kinase Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Ligation Lagging Strand Elongation Transcription-coupled Nucleotide-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining	Mitotic Cell Cycle Mitotic Cytokinesis Apoptotic Process Positive Regulation Of Protein Kinase Activity
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs		Bleomycin
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiographic traits ( 32602732) Night sleep phenotypes ( 27126917) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 19305408 29874175) TPE interval (resting) ( 32386560)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cooked vegetable consumption ( 32066663) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		8 interacting genes: APP JTB NEIL1 PARP1 TDP1 XRCC1 XRCC5 XRCC6	4 interacting genes: APP ELOC LIG3 ZXDC
Entrez ID		3980	10899
HPRD ID		02966	05240
Ensembl ID		ENSG00000005156	ENSG00000143543
Uniprot IDs		P49916	O76095
PDB IDs		1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG	2KJX
Enriched GO Terms of Interacting Partners?
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