LIG3 and NEIL1

Data Source:
BioGRID (two hybrid)

		LIG3	NEIL1
Description		DNA ligase 3	nei like DNA glycosylase 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion DNA Ligase III-XRCC1 Complex	Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center
	Molecular Function	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding	Damaged DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein C-terminus Binding Zinc Ion Binding Hydrolase Activity, Acting On Glycosyl Bonds DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Ligation Lagging Strand Elongation Transcription-coupled Nucleotide-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining	Base-excision Repair Response To Oxidative Stress Negative Regulation Of Nuclease Activity Depyrimidination
Pathways		Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective Base Excision Repair Associated with NEIL1
Drugs		Bleomycin	Iron Copper Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
Diseases
GWAS		Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiographic traits ( 32602732) Night sleep phenotypes ( 27126917) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 19305408 29874175) TPE interval (resting) ( 32386560)
Interacting Genes		8 interacting genes: APP JTB NEIL1 PARP1 TDP1 XRCC1 XRCC5 XRCC6	6 interacting genes: APP HUS1 LIG3 POLB RAD1 XRCC1
Entrez ID		3980	79661
HPRD ID		02966	12314
Ensembl ID		ENSG00000005156	ENSG00000140398
Uniprot IDs		P49916	Q96FI4
PDB IDs		1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG	1TDH 4NRV 5ITQ 5ITR 5ITT 5ITU 5ITX 5ITY
Enriched GO Terms of Interacting Partners?
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