TGFB1 and BMPR1A

Data Source:
BioGRID (two hybrid)

		TGFB1	BMPR1A
Description		transforming growth factor beta 1	bone morphogenetic protein receptor type 1A
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Golgi Lumen Plasma Membrane Microvillus Cell Surface Extracellular Matrix Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Blood Microparticle	Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body Receptor Complex HFE-transferrin Receptor Complex
	Molecular Function	Antigen Binding Type II Transforming Growth Factor Beta Receptor Binding Cytokine Activity Protein Binding Growth Factor Activity Enzyme Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Protein Homodimerization Activity SMAD Binding Metal Ion Binding BMP Receptor Activity
	Biological Process	MAPK Cascade Vasculogenesis Epithelial To Mesenchymal Transition Neural Tube Closure Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Chondrocyte Differentiation Hematopoietic Progenitor Cell Differentiation Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Platelet Degranulation Heart Valve Morphogenesis Aortic Valve Morphogenesis Protein Phosphorylation Protein Export From Nucleus ATP Biosynthetic Process Phosphate-containing Compound Metabolic Process Inflammatory Response Cell Cycle Arrest Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation SMAD Protein Complex Assembly Salivary Gland Morphogenesis Heart Development Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Response To Wounding Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Epithelial To Mesenchymal Transition Macrophage Derived Foam Cell Differentiation Positive Regulation Of Fibroblast Migration Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Macrophage Cytokine Production Positive Regulation Of Microglia Differentiation Regulation Of Striated Muscle Tissue Development Cell Migration Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Neural Tube Development Negative Regulation Of Cell-cell Adhesion Hyaluronan Catabolic Process Negative Regulation Of Cell Growth Regulation Of Cell Migration Positive Regulation Of Cell Migration Positive Regulation Of Bone Mineralization BMP Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Protein-containing Complex Assembly Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Response To Estradiol Response To Progesterone Positive Regulation Of Interleukin-17 Production Receptor Catabolic Process Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Protein Dephosphorylation Regulation Of Cell Population Proliferation Regulation Of Protein Import Into Nucleus Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Vascular Permeability Positive Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Phosphatidylinositol 3-kinase Activity Ossification Involved In Bone Remodeling Cell-cell Junction Organization Negative Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Myoblast Differentiation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Cytolysis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgA Isotypes Lymph Node Development Negative Regulation Of Skeletal Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Positive Regulation Of Chemotaxis Regulation Of Binding Regulation Of DNA Binding Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Ventricular Cardiac Muscle Tissue Morphogenesis Regulation Of Blood Vessel Remodeling Pathway-restricted SMAD Protein Phosphorylation Regulation Of SMAD Protein Signal Transduction Positive Regulation Of SMAD Protein Signal Transduction SMAD Protein Signal Transduction Negative Regulation Of Gene Silencing By MiRNA Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Response To Cholesterol Cellular Response To Organic Cyclic Compound Cellular Response To Transforming Growth Factor Beta Stimulus Extracellular Matrix Assembly Positive Regulation Of Canonical Wnt Signaling Pathway Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Hyaluronan Biosynthetic Process Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of NAD+ ADP-ribosyltransferase Activity Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Transforming Growth Factor Beta Receptor Signaling Pathway Involved In Heart Development Embryonic Liver Development Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Cardiac Muscle Cell Differentiation	In Utero Embryonic Development Mesoderm Formation Somitogenesis Mullerian Duct Regression Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Ventricular Compact Myocardium Morphogenesis Endocardial Cushion Formation Protein Phosphorylation Immune Response Transforming Growth Factor Beta Receptor Signaling Pathway Ectoderm Development Dorsal/ventral Axis Specification Dorsal/ventral Pattern Formation Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Neural Crest Cell Development Negative Regulation Of Smooth Muscle Cell Migration Stem Cell Population Maintenance Pituitary Gland Development Neural Plate Mediolateral Regionalization Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Hindlimb Morphogenesis Dorsal Aorta Morphogenesis Odontogenesis Of Dentin-containing Tooth Embryonic Digit Morphogenesis Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Paraxial Mesoderm Structural Organization Lateral Mesoderm Development Regulation Of Lateral Mesodermal Cell Fate Specification Mesendoderm Development Embryonic Organ Development Developmental Growth Positive Regulation Of Epithelial Cell Proliferation Negative Regulation Of Neurogenesis Roof Of Mouth Development Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of SMAD Protein Signal Transduction Heart Formation BMP Signaling Pathway Involved In Heart Development Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Cardiac Ventricle Development Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Fibrous Ring Of Heart Morphogenesis Regulation Of Neural Crest Cell Differentiation Regulation Of Cellular Senescence
Pathways		Platelet degranulation Influenza Virus Induced Apoptosis Cell surface interactions at the vascular wall Molecules associated with elastic fibres Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Syndecan interactions ECM proteoglycans SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer Transcriptional regulation of white adipocyte differentiation UCH proteinases Interleukin-4 and Interleukin-13 signaling RUNX3 regulates CDKN1A transcription Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF	Signaling by BMP
Drugs		Hyaluronidase (ovine) Terazosin Hyaluronidase (human recombinant) Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Hyaluronidase	Dibotermin alfa
Diseases		Graft-versus-host disease Allograft rejection Camurati-Engelmann disease; Progressive diaphyseal dysplasia	Hereditary mixed polyposis syndrome Juvenile polyposis syndrome
GWAS		Colorectal cancer ( 27145994 24836286) Colorectal cancer or advanced adenoma ( 30510241) Coronary artery disease ( 29212778 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Hematuria ( 30476138) Hematuria (mild) ( 30476138) Hematuria (moderate to severe) ( 30476138) Platelet count ( 32888494) Preterm birth (maternal effect) ( 28877031) Pulse pressure ( 30578418) Type 2 diabetes ( 31049640)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Refractive error ( 32231278) White blood cell count ( 32888494)
Interacting Genes		95 interacting genes: ACVRL1 ADAMTSL4 AGR3 ANGPTL4 APC APP AURKA AXIN2 BCAS3 BCL10 BGN BLID BMP2 BMP3 BMPR1A BUB1 CATSPER1 CCDC33 CCL3 CCL5 CCN2 CDKN2A COL2A1 CST6 CYSRT1 DAXX DCN DIRAS3 DLC1 DPT EGFR EIF3I ENG ERBB2 FBXW7 FCHO1 FCN1 FKBP1A FMOD FNTA GREB1 HOXA1 HOXC6 ITGAV ITGB6 ITGB8 KLK5 KLK7 KLK9 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP4-11 LAMTOR5 LCE1A LCE1C LCE1D LCE2B LCE2C LCE3A LCE3B LCE3D LPXN LTBP1 LTBP3 LTBP4 MCC MEOX2 MLH3 MMP2 MTA3 NSD3 P4HB PDGFRL PDLIM2 POU4F2 PRSS50 PSMC3IP PZP RAPGEF3 SCGB3A1 SDC2 SNAI1 SPARC ST14 TGFB2 TGFBR1 TGFBR2 TGFBR3 THBS1 THRSP TLR2 VASN VTN YWHAE	45 interacting genes: ACVR1 ALDOB AOPEP BAMBI BMP2 BMP4 BMP5 BMP6 BMP7 BMPR1B BMPR2 CDK8 CTSV FANCC FBP1 FBP2 FKBP1A FKBP1B GALNT12 GDF5 GDF6 GDF9 HOXC8 HRAS IGFBP3 MAP2K1 MSANTD3 NEDD4 NEDD4L OTUB1 RASA1 SEC61B SF3B4 SFRP2 SFRP4 SMAD1 TAB1 TDGF1 TGFB1 TGFBRAP1 TRMO USP15 XPA ZMYND11 ZNF189
Entrez ID		7040	657
HPRD ID		01821	03192
Ensembl ID		ENSG00000105329	ENSG00000107779
Uniprot IDs		A0A499FJK2 P01137	P36894
PDB IDs		1KLA 1KLC 1KLD 3KFD 4KV5 5FFO 5VQP 6OM2 6P7J	1ES7 1REW 2GOO 2H62 2H64 2K3G 2QJ9 2QJA 2QJB 3NH7 3QB4
Enriched GO Terms of Interacting Partners?
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