COPS6 and SULT1E1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		COPS6	SULT1E1
Description		COP9 signalosome subunit 6	sulfotransferase family 1E member 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Nuclear Membrane
	Molecular Function	Protein Binding Metallopeptidase Activity Isopeptidase Activity	Aryl Sulfotransferase Activity Estrone Sulfotransferase Activity Steroid Binding Protein Binding Sulfotransferase Activity Flavonol 3-sulfotransferase Activity Steroid Sulfotransferase Activity
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Viral Process Post-translational Protein Modification	Ethanol Catabolic Process Estrogen Catabolic Process Steroid Metabolic Process Estrogen Metabolic Process Positive Regulation Of Fat Cell Differentiation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process Sulfation
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Cytosolic sulfonation of small molecules
Drugs			Cyclizine Adenosine 3',5'-diphosphate 3'-phospho-5'-adenylyl sulfate 3,3',5,5'-tetrachlorobiphenyl-4,4'-diol
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Heel bone mineral density ( 30598549)
Interacting Genes		93 interacting genes: ANXA1 ANXA7 ASH2L BFSP2 BTBD2 C1orf174 C4orf17 CASP3 CASP6 CASP7 CASP8 CCBE1 CCDC106 CDH10 CDKN1A CDKN2C CHRNB1 COPS2 COPS3 COPS4 COPS5 COPS7B COPS8 COPS9 COX17 COX5A CRELD1 CUL1 CUL5 DIS3L2 DLEU1 EDN1 EIF3E EMD EP300 ERH FAU GPS1 HMOX2 LAMA4 LPL MAP3K1 MAP7D1 MAPK1 MAPK6 MAPKAPK3 MIF MNAT1 MYCBP NEDD8 NR3C1 ORAI2 PAEP PAFAH1B3 PBX2 PDZK1IP1 PFKL PHYHIP PMF1 PRKRA PSAP PSMD11 PTEN QTRT1 RAB27A RBX1 RFC5 ROGDI RPA2 RPL15 S100A10 SAT1 SERPINA5 SERPINB9 SHC3 SLC2A1 SMN1 SNRPG STK40 STX5 SULT1E1 TDGF1 TK1 TP53 TP63 TRDMT1 TRIB3 USHBP1 VIM WIPI2 ZEB2 ZFHX3 ZNF24	13 interacting genes: BMPR2 COPS6 EEF1A1 ENOX1 ERG28 IGSF21 LRIF1 PDE9A RBM48 SETDB1 SULT2B1 TP53 UNC119
Entrez ID		10980	6783
HPRD ID		16735	08966
Ensembl ID		ENSG00000168090	ENSG00000109193
Uniprot IDs		Q7L5N1	P49888 Q53X91
PDB IDs		4D10 4D18 4QFT 4R14 4WSN 6R6H 6R7F 6R7H 6R7I	1G3M 1HY3 4JVL 4JVM 4JVN
Enriched GO Terms of Interacting Partners?
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