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PLEKHA1 and CRKL
Data Source:
BioGRID
(two hybrid)
PLEKHA1
CRKL
Description
pleckstrin homology domain containing A1
CRK like proto-oncogene, adaptor protein
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Ruffle Membrane
Extracellular Exosome
Nucleoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Extrinsic Component Of Postsynaptic Membrane
Molecular Function
Protein Binding
Lipid Binding
PDZ Domain Binding
Phosphatidylinositol-3,4-bisphosphate Binding
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Identical Protein Binding
Cadherin Binding
Biological Process
Luteinization
Phosphatidylinositol Biosynthetic Process
Spermatogenesis
Androgen Metabolic Process
Estrogen Metabolic Process
Post-embryonic Development
Phosphatidylinositol 3-kinase Signaling
Ruffle Organization
Leydig Cell Differentiation
Multicellular Organism Growth
Establishment Of Protein Localization
Platelet-derived Growth Factor Receptor Signaling Pathway
Skeletal System Morphogenesis
B Cell Receptor Signaling Pathway
Negative Regulation Of Protein Kinase B Signaling
Roof Of Mouth Development
Face Morphogenesis
Cellular Response To Hydrogen Peroxide
Activation Of MAPKK Activity
Activation Of MAPK Activity
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Lipid Metabolic Process
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Synapse Assembly
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Anterior/posterior Pattern Specification
Negative Regulation Of Gene Expression
Dendrite Development
Cytokine-mediated Signaling Pathway
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Helper T Cell Diapedesis
Cellular Response To Drug
Reelin-mediated Signaling Pathway
Positive Regulation Of Ras Protein Signal Transduction
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Pharynx Development
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Transforming Growth Factor Beta Stimulus
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Acetylcholine Receptor Signaling Pathway
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
Pathways
Synthesis of PIPs at the plasma membrane
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Drugs
Citric acid
Diseases
GWAS
Age-related macular degeneration (
23577725
23536807
)
Age-related macular degeneration (extreme sampling) (
23577725
)
Autoimmune thyroid disease (
32581359
)
Birth weight (
31043758
27680694
)
Central corneal thickness (
32528159
)
Femoral neck bone mineral density (
29499414
)
Height (
31562340
20189936
)
Medication use (thyroid preparations) (
31015401
)
Offspring birth weight (
31043758
)
Refractive error (
32231278
)
Type 1 diabetes in high risk HLA genotype individuals (time to event) (
29310926
)
Type 2 diabetes (
28566273
24509480
30054458
30297969
32499647
30718926
28869590
)
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Interacting Genes
8 interacting genes:
CLDN14
CRKL
FBXO7
MPDZ
PLEKHA2
PTPN13
SH3BP4
SNTG1
79 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RIN3
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
Entrez ID
59338
1399
HPRD ID
09686
03596
Ensembl ID
ENSG00000107679
ENSG00000099942
Uniprot IDs
B3KQL5
Q5RGS4
Q9HB21
P46109
PDB IDs
1EAZ
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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