CRKL and INSR

Data Source:
HPRD (two hybrid)

		CRKL	INSR
Description		CRK like proto-oncogene, adaptor protein	insulin receptor
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Neuromuscular Junction Protein-containing Complex Extrinsic Component Of Postsynaptic Membrane	Nuclear Envelope Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Caveola External Side Of Plasma Membrane Endosome Membrane Membrane Axon Nuclear Lumen Dendrite Membrane Neuronal Cell Body Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding Protein Binding Identical Protein Binding Cadherin Binding	Amyloid-beta Binding Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor Receptor Binding Protein Binding ATP Binding GTP Binding Protein Domain Specific Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Cargo Receptor Activity Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding Protein-containing Complex Binding PTB Domain Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Lipid Metabolic Process JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Synapse Assembly Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Dendrite Development Cytokine-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Helper T Cell Diapedesis Cellular Response To Drug Reelin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Pharynx Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Endothelin Receptor Signaling Pathway Activation Of GTPase Activity Acetylcholine Receptor Signaling Pathway Cerebellar Neuron Development Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Internalization Heart Morphogenesis Carbohydrate Metabolic Process Regulation Of Transcription, DNA-templated Protein Phosphorylation Receptor-mediated Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Learning Memory Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Transformation Of Host Cell By Virus Positive Regulation Of Cell Migration Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Positive Regulation Of Kinase Activity Glucose Homeostasis Positive Regulation Of Protein-containing Complex Disassembly Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Embryonic Development Positive Regulation Of Glucose Import Protein Autophosphorylation Positive Regulation Of Developmental Growth Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Respiratory Burst Dendritic Spine Maintenance Amyloid-beta Clearance Transport Across Blood-brain Barrier Neuron Projection Maintenance
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling
Drugs			Insulin human Insulin lispro Insulin glargine Insulin pork Mecasermin Insulin aspart Insulin detemir Insulin glulisine Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate NN344 AT1391 [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Chromic chloride Insulin degludec Fostamatinib Brigatinib Mecasermin rinfabate
Diseases			Rabson-Mendenhall syndrome Leprechaunism ; Donohue syndrome
GWAS		Mean platelet volume ( 32888494) Platelet distribution width ( 32888494 27863252)	Asthma (childhood onset) ( 27142222) Birth weight ( 31043758) Blood urea nitrogen levels ( 31152163) Chronotype (sMEQ score) ( 32579418) Diabetic retinopathy ( 21441570) Diastolic blood pressure ( 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diffusing capacity of carbon monoxide ( 30694715) Diverticular disease ( 30177863) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Height ( 20881960 25282103 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 28552196 25673412) Hypertension ( 31879980) Hypothyroidism ( 27182965 22493691) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Perceived unattractiveness to mosquitoes ( 28199695) Polycystic ovary syndrome ( 22885925) Pulse pressure ( 27618448 30578418) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum uric acid levels ( 30993211) Systolic blood pressure ( 28135244 27841878 28739976 27618448 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549 28334899 32154731) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglycerides ( 24097068 30275531) Type 2 diabetes ( 30297969 32499647) Urate levels ( 31578528 23263486)
Interacting Genes		79 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RIN3 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1	86 interacting genes: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CCDC88A CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 DUSP18 DUSP19 ENPP1 ERBB2 FABP4 FRS2 GAB1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 MARCHF1 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF PTPRR RACK1 RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B STUB1 STYX SYNCRIP TEAD1 TRIM72 VAV1 VAV3 YWHAB
Entrez ID		1399	3643
HPRD ID		03596	00975
Ensembl ID		ENSG00000099942	ENSG00000171105
Uniprot IDs		P46109	P06213
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW	1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2HR7 2MFR 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3W11 3W12 3W13 4IBM 4OGA 4XLV 4XSS 4XST 4ZXB 5E1S 5HHW 5J3H 5KQV 5U1M 6HN4 6HN5 6PXV 6PXW 6SOF 6VEP 6VEQ
Enriched GO Terms of Interacting Partners?
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