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CRKL and GAB1
Data Source:
HPRD
(two hybrid)
CRKL
GAB1
Description
CRK like proto-oncogene, adaptor protein
GRB2 associated binding protein 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Extrinsic Component Of Postsynaptic Membrane
Cytosol
Cell-cell Junction
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Identical Protein Binding
Cadherin Binding
Protein Binding
Biological Process
Activation Of MAPKK Activity
Activation Of MAPK Activity
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Lipid Metabolic Process
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Synapse Assembly
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Anterior/posterior Pattern Specification
Negative Regulation Of Gene Expression
Dendrite Development
Cytokine-mediated Signaling Pathway
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Helper T Cell Diapedesis
Cellular Response To Drug
Reelin-mediated Signaling Pathway
Positive Regulation Of Ras Protein Signal Transduction
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Pharynx Development
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Transforming Growth Factor Beta Stimulus
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Acetylcholine Receptor Signaling Pathway
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
Angiogenesis
Epidermal Growth Factor Receptor Signaling Pathway
Axon Guidance
Insulin Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Actin Cytoskeleton Reorganization
Response To Hepatocyte Growth Factor
Vascular Endothelial Growth Factor Signaling Pathway
Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway
ERBB2 Signaling Pathway
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase B Signaling
Endothelial Cell Chemotaxis To Vascular Endothelial Growth Factor
Pathways
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
PI3K Cascade
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
PIP3 activates AKT signaling
GAB1 signalosome
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
PI-3K cascade:FGFR1
PI-3K cascade:FGFR2
PI-3K cascade:FGFR3
PI-3K cascade:FGFR4
Signaling by FGFR2 in disease
Signaling by FGFR4 in disease
Signaling by FGFR1 in disease
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
MET activates PI3K/AKT signaling
Signaling by FGFR3 fusions in cancer
Signaling by FGFR3 point mutants in cancer
RET signaling
MET activates PTPN11
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Activated NTRK2 signals through PI3K
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Drugs
Diseases
GWAS
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Asthma (
21804548
)
Diastolic blood pressure (
27841878
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
Height (
31562340
)
Malaria (
31844061
)
Systolic blood pressure (
27841878
)
Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Systolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Interacting Genes
79 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RIN3
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
73 interacting genes:
ARHGAP32
BCAR3
BLK
BLNK
BTK
C1QBP
CRK
CRKL
EGFR
EPOR
ERBB2
FCGR2B
FES
FRS2
GAB2
GRAP2
GRB2
GTF2A1L
HCK
HSH2D
INPP5D
INPPL1
INSR
ITK
JAK1
LAT2
LCK
LYN
MAP3K3
MAPK1
MAPK3
MAPK4
MARK2
MET
MST1R
NCK1
NCK2
PDGFRB
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLCG2
PTK6
PTPN11
PTPN18
RASA1
RET
SH2D1B
SH2D2A
SH2D3A
SHC1
SHC3
SLA
SLA2
SOCS3
SOCS6
SOS1
SRC
STAP1
SUPT6H
SYK
SYP
TEC
TNS1
TNS3
TNS4
TRIM15
VAV1
VAV2
VAV3
YES1
Entrez ID
1399
2549
HPRD ID
03596
05116
Ensembl ID
ENSG00000099942
ENSG00000109458
Uniprot IDs
P46109
Q13480
Q9HA84
PDB IDs
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
4QSY
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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