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CRKL and ITGB1
Data Source:
HPRD
(in vitro)
CRKL
ITGB1
Description
CRK like proto-oncogene, adaptor protein
integrin subunit beta 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Extrinsic Component Of Postsynaptic Membrane
Ruffle
Cytoplasm
Plasma Membrane
Focal Adhesion
Integrin Complex
Cell Surface
Membrane
Lamellipodium
Filopodium
Neuromuscular Junction
Cleavage Furrow
Ruffle Membrane
Integrin Alpha1-beta1 Complex
Integrin Alpha2-beta1 Complex
Integrin Alpha3-beta1 Complex
Integrin Alpha4-beta1 Complex
Integrin Alpha5-beta1 Complex
Integrin Alpha8-beta1 Complex
Integrin Alpha10-beta1 Complex
Integrin Alpha11-beta1 Complex
Sarcolemma
Melanosome
Receptor Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Recycling Endosome
Extracellular Exosome
Glial Cell Projection
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Identical Protein Binding
Cadherin Binding
Virus Receptor Activity
Fibronectin Binding
Protease Binding
Actin Binding
Integrin Binding
Protein Binding
Coreceptor Activity
C-X3-C Chemokine Binding
Laminin Binding
Protein-containing Complex Binding
Cadherin Binding
Metal Ion Binding
Protein Heterodimerization Activity
Cell Adhesion Molecule Binding
Collagen Binding Involved In Cell-matrix Adhesion
Protein Tyrosine Kinase Binding
Biological Process
Activation Of MAPKK Activity
Activation Of MAPK Activity
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Lipid Metabolic Process
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Synapse Assembly
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Anterior/posterior Pattern Specification
Negative Regulation Of Gene Expression
Dendrite Development
Cytokine-mediated Signaling Pathway
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Helper T Cell Diapedesis
Cellular Response To Drug
Reelin-mediated Signaling Pathway
Positive Regulation Of Ras Protein Signal Transduction
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Pharynx Development
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Transforming Growth Factor Beta Stimulus
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Acetylcholine Receptor Signaling Pathway
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
Establishment Of Mitotic Spindle Orientation
Phagocytosis
Cellular Defense Response
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Regulation Of Collagen Catabolic Process
Positive Regulation Of Fibroblast Migration
Cell Migration
Cytokine-mediated Signaling Pathway
CD40 Signaling Pathway
Cell Projection Organization
Lamellipodium Assembly
B Cell Differentiation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Cell-substrate Adhesion
Receptor Internalization
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Maintenance Of Blood-brain Barrier
Positive Regulation Of Apoptotic Process
Stress Fiber Assembly
Positive Regulation Of GTPase Activity
Positive Regulation Of Angiogenesis
Viral Entry Into Host Cell
Mesodermal Cell Differentiation
Regulation Of Immune Response
Leukocyte Migration
Leukocyte Tethering Or Rolling
Positive Regulation Of Protein Kinase B Signaling
Positive Regulation Of Glutamate Uptake Involved In Transmission Of Nerve Impulse
Cellular Response To Low-density Lipoprotein Particle Stimulus
Positive Regulation Of Wound Healing
Regulation Of Spontaneous Synaptic Transmission
Reactive Gliosis
Regulation Of Inward Rectifier Potassium Channel Activity
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Anoikis
Pathways
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Integrin cell surface interactions
Laminin interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Other semaphorin interactions
Signal transduction by L1
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
CHL1 interactions
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
Platelet Adhesion to exposed collagen
MET activates PTK2 signaling
MET interacts with TNS proteins
HCMV Early Events
Potential therapeutics for SARS
Drugs
Antithymocyte immunoglobulin (rabbit)
MK-0668
Diseases
GWAS
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Depression (quantitative trait) (
20800221
)
Suicide in bipolar disorder (
25917933
)
Interacting Genes
79 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RIN3
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
76 interacting genes:
ACAP1
ACTN1
ACTN4
ARHGAP5
CANX
CD151
CD36
CD46
CD82
CD9
CRKL
DAG1
DOK1
EGFR
ENO1
EPS8
FBLN1
FBXO2
FERMT1
FERMT2
FERMT3
FHL2
FLNA
FLNB
FLT4
FN1
HSPD1
HSPG2
ICAM4
IGF1R
ILK
ITGA1
ITGA10
ITGA11
ITGA2
ITGA3
ITGA4
ITGA5
ITGA6
ITGA8
ITGA9
ITGAV
ITGB1BP1
ITGB1BP2
LAMA1
LAMTOR5
LGALS1
LGALS3BP
LGALS8
MAP4K4
MET
NCKIPSD
NF2
NGF
NME1
NMRK2
PDHB
PIP5K1C
PLAUR
PRKCA
PRKCE
PTK2
PXN
RAB25
RACK1
SLC3A2
SPP1
TGM2
TGOLN2
TIMP2
TLN1
TSPAN4
UPF2
VCAM1
VCAN
YWHAB
Entrez ID
1399
3688
HPRD ID
03596
00628
Ensembl ID
ENSG00000099942
ENSG00000150093
Uniprot IDs
P46109
P05556
PDB IDs
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
1K11
1LHA
3G9W
3T9K
3VI3
3VI4
4DX9
4WJK
4WK0
4WK2
4WK4
Enriched GO Terms of Interacting Partners
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