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CRKL and NOTCH2
Data Source:
BioGRID
(two hybrid)
CRKL
NOTCH2
Description
CRK like proto-oncogene, adaptor protein
notch receptor 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Extrinsic Component Of Postsynaptic Membrane
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Endoplasmic Reticulum Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Cilium
Cell Surface
Membrane
Receptor Complex
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Identical Protein Binding
Cadherin Binding
Calcium Ion Binding
Protein Binding
Enzyme Binding
Signaling Receptor Activity
NF-kappaB Binding
Biological Process
Activation Of MAPKK Activity
Activation Of MAPK Activity
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Lipid Metabolic Process
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Synapse Assembly
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Anterior/posterior Pattern Specification
Negative Regulation Of Gene Expression
Dendrite Development
Cytokine-mediated Signaling Pathway
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Helper T Cell Diapedesis
Cellular Response To Drug
Reelin-mediated Signaling Pathway
Positive Regulation Of Ras Protein Signal Transduction
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Pharynx Development
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Transforming Growth Factor Beta Stimulus
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Acetylcholine Receptor Signaling Pathway
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
Negative Regulation Of Transcription By RNA Polymerase II
In Utero Embryonic Development
Cell Fate Determination
Heart Looping
Morphogenesis Of An Epithelial Sheet
Marginal Zone B Cell Differentiation
Inflammatory Response To Antigenic Stimulus
Pulmonary Valve Morphogenesis
Transcription Initiation From RNA Polymerase II Promoter
Apoptotic Process
Humoral Immune Response
Cell Cycle Arrest
Notch Signaling Pathway
Multicellular Organism Development
Nervous System Development
Axon Guidance
Animal Organ Morphogenesis
Negative Regulation Of Gene Expression
Positive Regulation Of Keratinocyte Proliferation
Stem Cell Population Maintenance
Hemopoiesis
Embryonic Limb Morphogenesis
Positive Regulation Of BMP Signaling Pathway
Multicellular Organism Growth
Intrahepatic Bile Duct Development
Wound Healing
Defense Response To Bacterium
Myeloid Dendritic Cell Differentiation
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Osteoclast Differentiation
Negative Regulation Of Growth Rate
Positive Regulation Of Ras Protein Signal Transduction
Bone Remodeling
Atrial Septum Morphogenesis
Placenta Blood Vessel Development
Ciliary Body Morphogenesis
Notch Signaling Involved In Heart Development
Positive Regulation Of ERK1 And ERK2 Cascade
Left/right Axis Specification
Proximal Tubule Development
Glomerular Visceral Epithelial Cell Development
Glomerular Capillary Formation
Hepatocyte Proliferation
Cholangiocyte Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Osteoclast Development
Pathways
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Pre-NOTCH Processing in the Endoplasmic Reticulum
Pre-NOTCH Transcription and Translation
Pre-NOTCH Processing in Golgi
Pre-NOTCH Processing in Golgi
NOTCH2 intracellular domain regulates transcription
NOTCH2 intracellular domain regulates transcription
NOTCH2 Activation and Transmission of Signal to the Nucleus
NOTCH2 Activation and Transmission of Signal to the Nucleus
Notch-HLH transcription pathway
Defective LFNG causes SCDO3
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Diseases
Alagille syndrome
Type II diabetes mellitus
Hajdu-Cheney syndrome
GWAS
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Blood protein levels (
30072576
)
Hepatocyte growth factor levels (
25998175
)
Nevus count or cutaneous melanoma (
32341527
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
18372903
30054458
30297969
)
Interacting Genes
79 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RIN3
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
31 interacting genes:
ANKRD28
CCR2
CNTN1
CRKL
CST6
DLL1
DTX1
DTX3
EGFL7
EPSTI1
GSK3B
IL13RA2
IL24
ITIH5
JAG1
JAG2
KLK5
LFNG
LRATD2
MAML1
MAML2
MAML3
MFNG
MTA3
MYOC
PSEN1
PSEN2
PSMC3IP
RBPJ
SMAD1
ST14
Entrez ID
1399
4853
HPRD ID
03596
02606
Ensembl ID
ENSG00000099942
ENSG00000134250
Uniprot IDs
P46109
Q04721
Q6IQ50
Q9UFD5
PDB IDs
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
2OO4
5MWB
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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