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CRKL and BLNK
Data Source:
HPRD
(in vivo)
CRKL
BLNK
Description
CRK like proto-oncogene, adaptor protein
B cell linker
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Extrinsic Component Of Postsynaptic Membrane
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Cytoplasmic Ribonucleoprotein Granule
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Identical Protein Binding
Cadherin Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Protein Binding
Enzyme Binding
Signaling Adaptor Activity
SH2 Domain Binding
Protein Tyrosine Kinase Binding
Biological Process
Activation Of MAPKK Activity
Activation Of MAPK Activity
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Lipid Metabolic Process
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Synapse Assembly
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Anterior/posterior Pattern Specification
Negative Regulation Of Gene Expression
Dendrite Development
Cytokine-mediated Signaling Pathway
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Helper T Cell Diapedesis
Cellular Response To Drug
Reelin-mediated Signaling Pathway
Positive Regulation Of Ras Protein Signal Transduction
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Pharynx Development
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Transforming Growth Factor Beta Stimulus
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Acetylcholine Receptor Signaling Pathway
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
Inflammatory Response
Humoral Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Gene Expression
B Cell Differentiation
Intracellular Signal Transduction
B Cell Receptor Signaling Pathway
Pathways
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Interacting Genes
79 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RIN3
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
25 interacting genes:
AR
BTK
CBL
CBLB
CD72
CD79A
CMTM3
CRKL
EGFR
ERBB2
ERBB3
GAB1
GRAP2
GRB2
ITK
KIT
LCP2
MAP4K1
NCK1
PLCG1
PLCG2
PTPN6
SH3KBP1
SYK
VAV1
Entrez ID
1399
29760
HPRD ID
03596
05153
Ensembl ID
ENSG00000099942
ENSG00000095585
Uniprot IDs
P46109
Q2MD54
Q2MD59
Q8WV28
PDB IDs
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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