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CRKL and BIK
Data Source:
BioGRID
(two hybrid)
CRKL
BIK
Description
CRK like proto-oncogene, adaptor protein
BCL2 interacting killer
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Neuromuscular Junction
Protein-containing Complex
Extrinsic Component Of Postsynaptic Membrane
Endomembrane System
Integral Component Of Membrane
Mitochondrial Membrane
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Protein Binding
Identical Protein Binding
Cadherin Binding
Protein Binding
Biological Process
Activation Of MAPKK Activity
Activation Of MAPK Activity
Regulation Of Cell Growth
Blood Vessel Development
Urogenital System Development
Neuron Migration
B Cell Apoptotic Process
Negative Regulation Of Protein Phosphorylation
Positive Regulation Of Protein Phosphorylation
Outflow Tract Morphogenesis
Lipid Metabolic Process
JNK Cascade
Ras Protein Signal Transduction
Spermatogenesis
Single Fertilization
Synapse Assembly
Positive Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Male Gonad Development
Anterior/posterior Pattern Specification
Negative Regulation Of Gene Expression
Dendrite Development
Cytokine-mediated Signaling Pathway
Hippocampus Development
Cerebral Cortex Development
Establishment Of Cell Polarity
Regulation Of Cell Adhesion Mediated By Integrin
Intracellular Signal Transduction
Helper T Cell Diapedesis
Cellular Response To Drug
Reelin-mediated Signaling Pathway
Positive Regulation Of Ras Protein Signal Transduction
Retinoic Acid Receptor Signaling Pathway
Thymus Development
Regulation Of Dendrite Development
T Cell Receptor Signaling Pathway
Parathyroid Gland Development
Cell Chemotaxis
Pharynx Development
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Transforming Growth Factor Beta Stimulus
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Acetylcholine Receptor Signaling Pathway
Cerebellar Neuron Development
Cellular Response To Interleukin-7
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Glial Cell Migration
Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Cranial Skeletal System Development
Regulation Of T Cell Migration
Apoptotic Process
Male Gonad Development
Apoptotic Mitochondrial Changes
Positive Regulation Of Protein-containing Complex Assembly
Regulation Of Apoptotic Process
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Pathways
Frs2-mediated activation
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
MET receptor recycling
Erythropoietin activates RAS
Erythropoietin activates RAS
Regulation of signaling by CBL
Drugs
Diseases
GWAS
Mean platelet volume (
32888494
)
Platelet distribution width (
32888494
27863252
)
Prostate cancer (
25939597
21743057
)
Prostate cancer (SNP x SNP interaction) (
22219177
)
Interacting Genes
79 interacting genes:
ABL1
AOX1
AREL1
ARHGAP32
BCAR1
BCR
BIK
BLK
BLNK
CBL
CBLB
CD34
CRK
DAB1
DOCK2
DOK1
DOK2
EPHB6
EPOR
ERBB2
ERBB3
ETV6
EVL
FCGR1A
GAB1
GAB2
GAREM1
GRB2
GRN
IFNAR1
IGF1R
INPP5D
INSR
IRS4
ITGB1
KHDRBS1
KIDINS220
KIT
LAMA5
LTBP4
LYN
MAP4K1
MAP4K5
MEGF6
MSL1
NEDD9
NOTCH2
PDGFRA
PHC2
PIK3R1
PIK3R2
PLEKHA1
PLSCR1
POLR1D
PPFIBP2
PSMC6
PTPDC1
PTPN11
PXN
RAPGEF1
RIN3
RPL31
SASH1
SHANK3
SHC1
SOS1
SOS2
STAT5A
STAT5B
SYK
TGFB1I1
TMEM168
TYK2
USP53
WAC
WAS
WIPF1
YES1
YY1
95 interacting genes:
ADGRE2
ADIPOQ
AIG1
ALG8
ANKRD46
APOD
APP
ASB11
BCL2
BCL2A1
BCL2L1
BCL2L10
BCL2L2
BMP10
BNIP3
BRICD5
BTN2A2
C14orf180
C3orf52
C4orf3
CD53
CD72
CLDN19
CMTM5
CMTM7
CNIH1
CNIH3
CREB3
CRKL
CTXN3
CXCL16
CYB561
CYB5B
ELOVL4
ERGIC3
EXOC3L2
FAM209A
FAM241B
FAM3C
FATE1
FCGR1A
GPX8
GRM2
INSIG2
KCNN4
MARCHF5
MCL1
MS4A13
NAT8
NR2F2
NRM
PBX3
PGAP2
PGRMC1
PLN
PLP1
PLP2
PLPP4
REEP4
RUSF1
S100A1
SCAMP4
SEC22A
SELENOK
SERP1
SERP2
SLC35E3
SLC37A4
SLC39A7
SMIM1
SOCS3
STRIT1
STX8
TANK
TMBIM1
TMEM107
TMEM11
TMEM14B
TMEM14C
TMEM199
TMEM222
TMEM229B
TMEM243
TMEM254
TMEM60
TMEM80
TMEM86B
TMEM97
TRARG1
TSPO2
UBE2D1
UBIAD1
VAMP3
VAMP5
ZFPL1
Entrez ID
1399
638
HPRD ID
03596
04547
Ensembl ID
ENSG00000099942
ENSG00000100290
Uniprot IDs
P46109
A0A024R4X6
Q13323
PDB IDs
2BZX
2BZY
2DBK
2EO3
2LQN
2LQW
2IPE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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