CRKL and EVL

Data Source:
HPRD (in vitro)

		CRKL	EVL
Description		CRK like proto-oncogene, adaptor protein	Enah/Vasp-like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Neuromuscular Junction Protein-containing Complex Extrinsic Component Of Postsynaptic Membrane	Cytoplasm Cytosol Cytoskeleton Focal Adhesion Membrane Lamellipodium
	Molecular Function	Phosphotyrosine Residue Binding RNA Binding Protein Binding Identical Protein Binding Cadherin Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding
	Biological Process	Activation Of MAPKK Activity Activation Of MAPK Activity Regulation Of Cell Growth Blood Vessel Development Urogenital System Development Neuron Migration B Cell Apoptotic Process Negative Regulation Of Protein Phosphorylation Positive Regulation Of Protein Phosphorylation Outflow Tract Morphogenesis Lipid Metabolic Process JNK Cascade Ras Protein Signal Transduction Spermatogenesis Single Fertilization Synapse Assembly Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Anterior/posterior Pattern Specification Negative Regulation Of Gene Expression Dendrite Development Cytokine-mediated Signaling Pathway Hippocampus Development Cerebral Cortex Development Establishment Of Cell Polarity Regulation Of Cell Adhesion Mediated By Integrin Intracellular Signal Transduction Helper T Cell Diapedesis Cellular Response To Drug Reelin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Retinoic Acid Receptor Signaling Pathway Thymus Development Regulation Of Dendrite Development T Cell Receptor Signaling Pathway Parathyroid Gland Development Cell Chemotaxis Pharynx Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Transforming Growth Factor Beta Stimulus Endothelin Receptor Signaling Pathway Activation Of GTPase Activity Acetylcholine Receptor Signaling Pathway Cerebellar Neuron Development Cellular Response To Interleukin-7 Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Glial Cell Migration Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Cranial Skeletal System Development Regulation Of T Cell Migration	Actin Filament Organization Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Actin Polymerization Or Depolymerization Animal Organ Morphogenesis Negative Regulation Of Epithelial Cell Migration Positive Regulation Of Actin Filament Polymerization Actin Nucleation Protein Homotetramerization Positive Regulation Of Stress Fiber Assembly Negative Regulation Of Ruffle Assembly
Pathways		Frs2-mediated activation Frs2-mediated activation Downstream signal transduction MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors RHO GTPases Activate Formins
Drugs
Diseases
GWAS		Mean platelet volume ( 32888494) Platelet distribution width ( 32888494 27863252)	Blood protein levels ( 30072576) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218)
Interacting Genes		79 interacting genes: ABL1 AOX1 AREL1 ARHGAP32 BCAR1 BCR BIK BLK BLNK CBL CBLB CD34 CRK DAB1 DOCK2 DOK1 DOK2 EPHB6 EPOR ERBB2 ERBB3 ETV6 EVL FCGR1A GAB1 GAB2 GAREM1 GRB2 GRN IFNAR1 IGF1R INPP5D INSR IRS4 ITGB1 KHDRBS1 KIDINS220 KIT LAMA5 LTBP4 LYN MAP4K1 MAP4K5 MEGF6 MSL1 NEDD9 NOTCH2 PDGFRA PHC2 PIK3R1 PIK3R2 PLEKHA1 PLSCR1 POLR1D PPFIBP2 PSMC6 PTPDC1 PTPN11 PXN RAPGEF1 RIN3 RPL31 SASH1 SHANK3 SHC1 SOS1 SOS2 STAT5A STAT5B SYK TGFB1I1 TMEM168 TYK2 USP53 WAC WAS WIPF1 YES1 YY1	33 interacting genes: ABI1 ABI3 ABL1 APBB1 APBB1IP CRKL DNMBP ENAH FYB1 FYN HCK HTT LYN PFN2 POT1 PRPF40A RAD51 SEMA6A SH3RF1 SPTA1 SPTAN1 SRC TCERG1 TERF1 TES TRIM9 VASP WAS WASL XIRP1 ZDHHC17 ZNF655 ZYX
Entrez ID		1399	51466
HPRD ID		03596	10942
Ensembl ID		ENSG00000099942	ENSG00000196405
Uniprot IDs		P46109	A0A024R6K5 Q9UI08
PDB IDs		2BZX 2BZY 2DBK 2EO3 2LQN 2LQW
Enriched GO Terms of Interacting Partners?
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