RAP2B and RALGDS

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vivo, in vitro, two hybrid)

		RAP2B	RALGDS
Description		RAP2B, member of RAS oncogene family	ral guanine nucleotide dissociation stimulator
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Nucleus Cytosol Brush Border
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity
	Biological Process	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Neutrophil Degranulation Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Ras Protein Signal Transduction Regulation Of Catalytic Activity
Pathways		Neutrophil degranulation	p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		9 interacting genes: CAMK2B PDE6D RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2
Entrez ID		5912	5900
HPRD ID		01548	03371
Ensembl ID		ENSG00000181467	ENSG00000160271
Uniprot IDs		P61225	Q12967 Q8N4Y1
PDB IDs		1N4P 1N4Q 1N4R	1RAX 2B3A 2RGF 3KH0
Enriched GO Terms of Interacting Partners?
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