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RAP2B and CAMK2B
Data Source:
BioGRID
(two hybrid, two hybrid)
RAP2B
CAMK2B
Description
RAP2B, member of RAS oncogene family
calcium/calmodulin dependent protein kinase II beta
Image
GO Annotations
Cellular Component
Cytosol
Plasma Membrane
Bicellular Tight Junction
Membrane
Specific Granule Membrane
Cell-cell Contact Zone
Membrane Raft
Recycling Endosome Membrane
Extracellular Exosome
Tertiary Granule Membrane
Nucleoplasm
Cytoplasm
Microtubule Organizing Center
Cytosol
Calcium- And Calmodulin-dependent Protein Kinase Complex
Endocytic Vesicle Membrane
Sarcoplasmic Reticulum Membrane
Neuron Projection
Synapse
Molecular Function
GTPase Activity
Protein Binding
GTP Binding
GDP Binding
Protein Domain Specific Binding
Actin Binding
Calmodulin-dependent Protein Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Identical Protein Binding
Protein Homodimerization Activity
Biological Process
Signal Transduction
Microvillus Assembly
Platelet Activation
Negative Regulation Of Cell Migration
Positive Regulation Of Protein Autophosphorylation
Rap Protein Signal Transduction
Neutrophil Degranulation
Regulation Of Protein Tyrosine Kinase Activity
Platelet Aggregation
Establishment Of Endothelial Intestinal Barrier
Protein Phosphorylation
Signal Transduction
Positive Regulation Of Neuron Projection Development
Regulation Of Skeletal Muscle Adaptation
Protein Autophosphorylation
Regulation Of Long-term Neuronal Synaptic Plasticity
Regulation Of Synapse Structural Plasticity
Regulation Of Calcium Ion Transport
Interferon-gamma-mediated Signaling Pathway
Regulation Of Dendritic Spine Development
Positive Regulation Of Dendritic Spine Morphogenesis
Positive Regulation Of Synapse Maturation
Regulation Of Cellular Response To Heat
Regulation Of Neuron Migration
Pathways
Neutrophil degranulation
CaMK IV-mediated phosphorylation of CREB
HSF1-dependent transactivation
Trafficking of AMPA receptors
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
Ras activation upon Ca2+ influx through NMDA receptor
Phase 0 - rapid depolarisation
Ion homeostasis
RAF activation
RAF/MAP kinase cascade
Signaling by moderate kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Interferon gamma signaling
Regulation of MECP2 expression and activity
Ion transport by P-type ATPases
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
[4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
Fostamatinib
Diseases
GWAS
Cerebral amyloid deposition (PET imaging) (
30361487
)
Chronotype (
30696823
)
Cutaneous melanoma or hair colour (
32341527
)
Metabolite levels (
23823483
)
PR interval (
32439900
)
Serum sulfate level (
27412988
)
Cerebrospinal fluid p-tau levels in mild cognitive impairment (
29274321
)
Intracranial aneurysm (
29531279
)
Metabolic syndrome (
22399527
)
Osteoarthritis (hip) (
23989986
)
Systolic blood pressure (
30578418
)
Triglyceride levels (
32203549
)
Interacting Genes
9 interacting genes:
CAMK2B
PDE6D
RALGDS
RAP1GDS1
RAPGEF1
RAPGEF2
RAPGEF5
RASSF5
RUNDC3A
56 interacting genes:
ACOT7
ACTN4
AP5B1
ARSA
ATXN1
CAMK2A
CAMK2D
CAMK2G
CAMK2N2
CCM2L
CDC37
COL4A3
DUS1L
ETS1
FAM171A2
GAPDH
GRIN2A
GRIN2B
ITPKA
KRT86
KRTAP1-1
KRTAP10-11
KRTAP19-3
KRTAP19-5
KRTAP19-7
KRTAP6-2
KRTAP6-3
MAD2L2
MED18
MEOX2
MGAT5B
MORF4L1
MORF4L2
MRPL11
MVP
PHKB
PLCB3
PNKP
POLR3C
POP5
RAP2B
RBFOX2
RBPMS
RNF4
RPL11
RXRG
SEMA4G
SMYD3
SPRYD7
THRB
TNPO2
TNPO3
TTC5
YWHAB
ZBTB32
ZMYM5
Entrez ID
5912
816
HPRD ID
01548
12127
Ensembl ID
ENSG00000181467
ENSG00000058404
Uniprot IDs
P61225
A4D2J9
B7Z1Z6
Q13554
PDB IDs
1N4P
1N4Q
1N4R
3BHH
Enriched GO Terms of Interacting Partners
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