RALGDS and RAP1GAP

Data Source:
HPRD (in vitro)

		RALGDS	RAP1GAP
Description		ral guanine nucleotide dissociation stimulator	RAP1 GTPase activating protein
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GO Annotations	Cellular Component	Nucleus Cytosol Brush Border	Golgi Membrane Cytoplasm Cytosol Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	GTPase Activity GTPase Activator Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity
	Biological Process	Ras Protein Signal Transduction Regulation Of Catalytic Activity	Signal Transduction Axon Guidance Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity Negative Regulation Of Microvillus Assembly
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade	Rap1 signalling RET signaling
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Abdominal aortic calcification levels ( 31659325) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Liver enzyme levels ( 18940312) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Serum alkaline phosphatase levels ( 31666285)
Interacting Genes		26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2	15 interacting genes: AFDN BRAF CDK1 CSNK1G2 DYNC1I1 GNAZ MAP1LC3B MAPK6 MEX3B PFN2 PLK1 PRKACA RALGDS RAP1A ZBTB12
Entrez ID		5900	5909
HPRD ID		03371	02609
Ensembl ID		ENSG00000160271	ENSG00000076864
Uniprot IDs		Q12967 Q8N4Y1	A0A024RAB5 P47736 X6R8W7
PDB IDs		1RAX 2B3A 2RGF 3KH0	1SRQ 3BRW
Enriched GO Terms of Interacting Partners?
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