RALGDS and RAP2B

Data Source:
BioGRID (two hybrid, pull down)
HPRD (in vivo, in vitro, two hybrid)

		RALGDS	RAP2B
Description		ral guanine nucleotide dissociation stimulator	RAP2B, member of RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Cytosol Brush Border	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding
	Biological Process	Ras Protein Signal Transduction Regulation Of Catalytic Activity	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Neutrophil Degranulation Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade	Neutrophil degranulation
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)
Interacting Genes		26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2	9 interacting genes: CAMK2B PDE6D RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A
Entrez ID		5900	5912
HPRD ID		03371	01548
Ensembl ID		ENSG00000160271	ENSG00000181467
Uniprot IDs		Q12967 Q8N4Y1	P61225
PDB IDs		1RAX 2B3A 2RGF 3KH0	1N4P 1N4Q 1N4R
Enriched GO Terms of Interacting Partners?
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