RAP2B and RAPGEF5

Data Source:
HPRD (in vitro)

		RAP2B	RAPGEF5
Description		RAP2B, member of RAS oncogene family	Rap guanine nucleotide exchange factor 5
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Nucleus Nucleoplasm Nuclear Body
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding	Guanyl-nucleotide Exchange Factor Activity GTP-dependent Protein Binding
	Biological Process	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Neutrophil Degranulation Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Small GTPase Mediated Signal Transduction Nervous System Development Regulation Of Catalytic Activity
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Cutaneous malignant melanoma ( 32341527) Depression in smokers ( 30219690) Dialysis-related mortality ( 21546767) Diastolic blood pressure ( 30224653) Glaucoma ( 30104761) Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Night sleep phenotypes ( 27126917) Spatial processing ( 31596458) Squamous cell lung carcinoma ( 28604730) Thyroid stimulating hormone levels ( 17903292) Urinary albumin excretion ( 32277301)
Interacting Genes		9 interacting genes: CAMK2B PDE6D RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	7 interacting genes: MRAS PLAC9 RAP1A RAP2A RAP2B TMEM253 VANGL1
Entrez ID		5912	9771
HPRD ID		01548	15208
Ensembl ID		ENSG00000181467	ENSG00000136237
Uniprot IDs		P61225	A8MQ07 Q5JPD2 Q92565
PDB IDs		1N4P 1N4Q 1N4R	1WGY
Enriched GO Terms of Interacting Partners?
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