RAP2B and RASSF5

Data Source:
BioGRID (two hybrid)

		RAP2B	RASSF5
Description		RAP2B, member of RAS oncogene family	Ras association domain family member 5
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Bicellular Tight Junction Membrane Specific Granule Membrane Cell-cell Contact Zone Membrane Raft Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Nucleus Cytoplasm Microtubule
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Protein Domain Specific Binding	Protein Binding Metal Ion Binding
	Biological Process	Signal Transduction Microvillus Assembly Platelet Activation Negative Regulation Of Cell Migration Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Neutrophil Degranulation Regulation Of Protein Tyrosine Kinase Activity Platelet Aggregation Establishment Of Endothelial Intestinal Barrier	Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Intracellular Signal Transduction Regulation Of Apoptotic Process Regulation Of Protein Localization To Nucleus
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 30361487) Chronotype ( 30696823) Cutaneous melanoma or hair colour ( 32341527) Metabolite levels ( 23823483) PR interval ( 32439900) Serum sulfate level ( 27412988)	Inflammatory bowel disease ( 23128233) Late-onset Alzheimer's disease ( 27770636) Neurofibrillary tangles ( 25188341)
Interacting Genes		9 interacting genes: CAMK2B PDE6D RALGDS RAP1GDS1 RAPGEF1 RAPGEF2 RAPGEF5 RASSF5 RUNDC3A	31 interacting genes: ADH6 AMOTL2 APPBP2 BTRC HRAS ITCH KRAS KRT40 KRTAP4-2 LSM7 MRAS MYLIP NRAS RABIF RALA RAP1B RAP2A RAP2B RASSF1 RASSF2 REL RRAS RRAS2 SMAD4 STK4 TERF2IP TRAF1 TRAF2 UBQLN1 UBQLN2 VPS28
Entrez ID		5912	83593
HPRD ID		01548	06117
Ensembl ID		ENSG00000181467	ENSG00000266094
Uniprot IDs		P61225	A8K5F3 Q8WWW0
PDB IDs		1N4P 1N4Q 1N4R	4LGD 4OH8
Enriched GO Terms of Interacting Partners?
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