RALGDS and RAP2A

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		RALGDS	RAP2A
Description		ral guanine nucleotide dissociation stimulator	RAP2A, member of RAS oncogene family
Image
GO Annotations	Cellular Component	Nucleus Cytosol Brush Border	Cytosol Plasma Membrane Midbody Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTPase Regulator Activity	Magnesium Ion Binding GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Ras Protein Signal Transduction Regulation Of Catalytic Activity	Positive Regulation Of Protein Phosphorylation Microvillus Assembly Negative Regulation Of Cell Migration Actin Cytoskeleton Reorganization Positive Regulation Of Protein Autophosphorylation Rap Protein Signal Transduction Cellular Protein Localization Cellular Response To Drug Establishment Of Protein Localization Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of JNK Cascade Regulation Of Dendrite Morphogenesis Protein Localization To Plasma Membrane
Pathways		p38MAPK events p38MAPK events RAF/MAP kinase cascade
Drugs			Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058)	Gut microbiota (bacterial taxa) ( 27723756) Peripheral artery disease ( 26488411)
Interacting Genes		26 interacting genes: AFDN ARRB1 ARRB2 CD68 CNKSR1 CYSRT1 HOXA1 HRAS KRAS KRTAP10-8 LRPAP1 MAPK3 MRAS NF2 PDPK1 RAP1A RAP1B RAP1GAP RAP2A RAP2B RAPGEF2 RIN1 RIT1 RIT2 RRAS RRAS2	32 interacting genes: ACVR1 AFDN ARHGAP29 BMPR1B EEF1A1 ENSA FKBP2 FNTB FTL GABARAPL2 GRIN1 GRIN2D MAP4K4 NEDD4 PLG RAF1 RALGDS RAPGEF3 RAPGEF4 RAPGEF5 RAPGEF6 RASIP1 RASSF5 RGL1 RGS14 RRP9 RUNDC3A SERPINA1 SMAD1 TGFBR1 TM7SF2 TNIK
Entrez ID		5900	5911
HPRD ID		03371	01547
Ensembl ID		ENSG00000160271	ENSG00000125249
Uniprot IDs		Q12967 Q8N4Y1	P10114
PDB IDs		1RAX 2B3A 2RGF 3KH0	1KAO 2RAP 3RAP
Enriched GO Terms of Interacting Partners?
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