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CBX8 and FHL3
Data Source:
BioGRID
(two hybrid)
CBX8
FHL3
Description
chromobox 8
four and a half LIM domains 3
Image
GO Annotations
Cellular Component
Chromatin
Heterochromatin
Nucleus
Nucleoplasm
PcG Protein Complex
PRC1 Complex
Stress Fiber
Nucleus
Focal Adhesion
Z Disc
Molecular Function
Single-stranded RNA Binding
Protein Binding
Methylated Histone Binding
Ubiquitin-protein Transferase Activator Activity
Transcription Coregulator Activity
Actin Binding
Protein Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cell Population Proliferation
Histone Ubiquitination
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of DNA Repair
Regulation Of Catalytic Activity
Cellular Response To Hydrogen Peroxide
Regulation Of Transcription, DNA-templated
Muscle Organ Development
Actin Cytoskeleton Organization
Pathways
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
General risk tolerance (MTAG) (
30643258
)
Plateletcrit (
32888494
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Smoking status (ever vs never smokers) (
30643258
)
Youthful appearance (self-reported) (
32339537
)
Coronary artery disease (
29212778
33020668
)
Pulse pressure (
30578418
)
Interacting Genes
87 interacting genes:
ABLIM3
BACH2
BANP
BMI1
CALCOCO2
CARD10
CARD9
CCDC136
CCDC57
CEP70
DVL3
EEF1G
FHL3
FSD2
FXR1
GIGYF1
GOLGA2
GOLGA6L9
GPRASP2
GRIPAP1
H3-4
HAP1
HMBOX1
HOMEZ
HOOK2
HSF2BP
IKZF1
JADE2
JAKMIP1
KANK2
KAT5
KAT7
KCTD9
KIFC3
KRT31
KRT34
KRT40
LSM2
LZTS2
MB21D2
MCC
MDFI
MID2
MLLT1
MLLT3
MTUS2
NAB2
PAXIP1
PCGF5
PHACTR1
PIBF1
PICK1
PIH1D2
PLEKHF2
PNMA1
PNMA2
POLR1C
PRDM6
PRKAR1B
RASSF3
RING1
RPGRIP1
SESTD1
SETDB1
SOX5
TAX1BP1
TEPSIN
TFCP2
TFIP11
TRAF2
TRIB3
TRIM23
TRIM27
TRIM54
TSC22D4
TSGA10
TTC23
UNC119
USH1G
USP11
USP7
VIM
ZBTB14
ZBTB8A
ZBTB9
ZNF185
ZRANB1
181 interacting genes:
A1CF
ACTB
ADAM15
ADAMTSL4
AIMP2
AMBP
ANKHD1
ARHGEF10
ARID5A
ASCL4
BARX2
C1orf94
C9orf116
CASS4
CBX8
CCDC198
CCND3
CDC25B
CDC42EP1
CDKN1A
CDKN2D
CHEK2
CLCN2
CNNM3
CNOT7
CORO1A
CREB5
CRIP3
CRYBA2
CSF1
CTBP2
CYSRT1
DCDC2B
DLGAP4
DMRT3
DUX4L9
E2F8
EFCAB12
EIF4EBP2
EPHA10
EPM2AIP1
ERBB3
EXOSC1
EXOSC5
FADS6
FAM110A
FAM126A
FAM222B
FAM71C
FAM90A1
FBXL18
FHL2
FOS
FOSL2
FOXN4
GATA1
GATA2
GCM2
GUCD1
HAPLN2
HIPK1
HOXA1
HSF2BP
HYAL2
IHO1
IKZF3
ITGA7
ITGB5
KANK2
KIDINS220
KIRREL2
KLF12
KLF3
KLF8
KPRP
KRTAP12-1
KRTAP12-2
KTI12
LASP1
LATS2
LHB
LMO2
LMO4
LNX1
LNX2
MAPK1
MED15
MMP14
MORF4L1
MPZL1
MRM3
MRPL27
MRRF
MSRB3
MTA1
MTUS2
MYBPC1
MYBPHL
MYOZ3
MYPOP
MZF1
NDUFAB1
NFKBIB
NPRL3
ODF3B
P4HA2
PAK5
PATL1
PHC2
PHF21A
PIAS1
PKP2
PLEKHF2
PLEKHG4B
POLR1H
PPIG
PPP1R32
PRR35
PRR5L
PTPN6
QKI
QRICH1
RAB40B
RAD21
RASL12
RBM42
RFX3
RFX6
RHEBL1
RSPH14
RYBP
SAP30BP
SAXO1
SBF2
SDCBP
SH3GLB2
SHE
SLAIN1
SLC25A46
SLC44A3
SLU7
SMAD2
SMAD3
SMAD4
SNRPB
SNRPC
SNRPG
SPATA8
SREBF2
SRF
SRGN
SUPT5H
TBC1D22B
THAP7
THEG
TLE5
TMEM108
TMEM14B
TMSB4X
TMX3
TOPBP1
TRAF3IP2
TRIM27
TRIP6
TRO
TSGA10IP
TTLL10
TUBA3E
TYK2
TYMSOS
UBE2I
UBE2Q1
VWC2L
WDR25
WNK1
YPEL3
ZCCHC14
ZFP36
ZNF417
ZNF512B
ZNF587
Entrez ID
57332
2275
HPRD ID
13006
09101
Ensembl ID
ENSG00000141570
ENSG00000183386
Uniprot IDs
Q9HC52
Q13643
Q96C98
PDB IDs
2N4Q
3I91
5EQ0
1WYH
2CUQ
2EHE
Enriched GO Terms of Interacting Partners
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