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PTAFR and GRIN1
Data Source:
BioGRID
(two hybrid)
PTAFR
GRIN1
Description
platelet activating factor receptor
glutamate ionotropic receptor NMDA type subunit 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Integral Component Of Membrane
Secretory Granule Membrane
Tertiary Granule Membrane
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Dendrite
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Molecular Function
Lipopolysaccharide Binding
Lipopolysaccharide Immune Receptor Activity
G Protein-coupled Receptor Activity
Platelet Activating Factor Receptor Activity
Protein Binding
Phospholipid Binding
G Protein-coupled Purinergic Nucleotide Receptor Activity
Mitogen-activated Protein Kinase Binding
Amyloid-beta Binding
NMDA Glutamate Receptor Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Ligand-gated Ion Channel Activity
Glycine Binding
Glutamate Binding
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Neurotransmitter Binding
Protein-containing Complex Binding
Biological Process
Positive Regulation Of Cellular Extravasation
Regulation Of Transcription By RNA Polymerase II
Chemotaxis
Inflammatory Response
Immune Response
G Protein-coupled Receptor Signaling Pathway
Parturition
Response To Symbiotic Bacterium
Positive Regulation Of Phospholipase C Activity
Cytokine-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Inositol Trisphosphate Biosynthetic Process
G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway
Neutrophil Degranulation
Positive Regulation Of Neutrophil Degranulation
Transcytosis
Positive Regulation Of Translation
Negative Regulation Of Blood Pressure
Positive Regulation Of Vasoconstriction
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Smooth Muscle Cell Proliferation
Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Cellular Response To Gravity
Cellular Response To CAMP
Cellular Response To Fatty Acid
Response To Dexamethasone
Positive Regulation Of Voltage-gated Chloride Channel Activity
Positive Regulation Of Leukocyte Tethering Or Rolling
Positive Regulation Of Sensory Perception Of Pain
Positive Regulation Of Transcytosis
Positive Regulation Of Maternal Process Involved In Parturition
Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction
Cellular Response To 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine
MAPK Cascade
Cation Transport
Chemical Synaptic Transmission
Brain Development
Visual Learning
Positive Regulation Of Calcium Ion Transport Into Cytosol
Propylene Metabolic Process
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Membrane Potential
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Ephrin Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Protein Heterotetramerization
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Response To Glycine
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
Interleukin-10 signaling
Neutrophil degranulation
Interferon gamma signaling
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Platelet Activating Factor
Etizolam
Rupatadine
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Prasterone
5,7-Dichlorokynurenic acid
D-Serine
Cycloleucine
Milnacipran
CNS-5161
Acetylcysteine
Ketobemidone
Gavestinel
Agmatine
Ifenprodil
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
GWAS
Blond vs. brown/black hair color (
30531825
)
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Interacting Genes
19 interacting genes:
ARR3
ARRB2
CALM1
GORAB
GRIN1
GTPBP3
IFITM3
MBP
MFSD3
PLLP
PPM1J
PRNP
RGS4
RHBDD2
SERINC5
SPATA24
TMEM120A
TMX2
TYK2
57 interacting genes:
ACTN2
AKAP9
APP
BDKRB1
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
PTAFR
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
Entrez ID
5724
2902
HPRD ID
01422
15926
Ensembl ID
ENSG00000169403
ENSG00000176884
Uniprot IDs
A8K7N8
P25105
Q05586
Q59GW0
Q5VSF9
PDB IDs
2B0X
2HQW
2NR1
3BYA
5H8F
5H8H
5H8N
5H8Q
5I2K
5I2N
5KCJ
5KDT
5TP9
5TPA
6IRA
6IRF
6IRG
6IRH
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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