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GRIN1 and CDH2
Data Source:
HPRD
(in vivo)
GRIN1
CDH2
Description
glutamate ionotropic receptor NMDA type subunit 1
cadherin 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Dendrite
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Cytoplasm
Endoplasmic Reticulum Lumen
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Adherens Junction
Fascia Adherens
Focal Adhesion
Cell Surface
Postsynaptic Density
Intercalated Disc
Basolateral Plasma Membrane
Apical Plasma Membrane
Apicolateral Plasma Membrane
Catenin Complex
Lamellipodium
Cell Junction
Cortical Actin Cytoskeleton
Sarcolemma
Neuron Projection
Plasma Membrane Raft
Apical Part Of Cell
Collagen-containing Extracellular Matrix
Integral Component Of Presynaptic Active Zone Membrane
Integral Component Of Postsynaptic Specialization Membrane
Molecular Function
Amyloid-beta Binding
NMDA Glutamate Receptor Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Ligand-gated Ion Channel Activity
Glycine Binding
Glutamate Binding
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Neurotransmitter Binding
Protein-containing Complex Binding
Calcium Ion Binding
Protein Binding
Beta-catenin Binding
Protein Kinase Binding
Protein Phosphatase Binding
Identical Protein Binding
Alpha-catenin Binding
Gamma-catenin Binding
Cadherin Binding
Biological Process
MAPK Cascade
Cation Transport
Chemical Synaptic Transmission
Brain Development
Visual Learning
Positive Regulation Of Calcium Ion Transport Into Cytosol
Propylene Metabolic Process
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Membrane Potential
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Ephrin Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Protein Heterotetramerization
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Response To Glycine
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Cysteine-type Endopeptidase Activity
Type B Pancreatic Cell Development
Cell-cell Junction Assembly
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Synapse Assembly
Brain Development
Glial Cell Differentiation
Neural Crest Cell Development
Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
Cerebral Cortex Development
Adherens Junction Organization
Detection Of Muscle Stretch
Positive Regulation Of MAPK Cascade
Post-translational Protein Modification
Cellular Protein Metabolic Process
Cell-cell Adhesion Mediated By Cadherin
Blood Vessel Morphogenesis
Brain Morphogenesis
Homeostasis Of Number Of Cells
Regulation Of Axonogenesis
Striated Muscle Cell Differentiation
Positive Regulation Of Muscle Cell Differentiation
Regulation Of Synaptic Transmission, Glutamatergic
Radial Glial Cell Differentiation
Neuroepithelial Cell Differentiation
Regulation Of Oligodendrocyte Progenitor Proliferation
Protein Localization To Plasma Membrane
Negative Regulation Of Canonical Wnt Signaling Pathway
Mesenchymal Cell Migration
Neuroligin Clustering Involved In Postsynaptic Membrane Assembly
Neuronal Stem Cell Population Maintenance
Cell-cell Adhesion
Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
Regulation Of Postsynaptic Density Protein 95 Clustering
Positive Regulation Of Synaptic Vesicle Clustering
Pathways
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Adherens junctions interactions
Myogenesis
Myogenesis
Post-translational protein phosphorylation
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Prasterone
5,7-Dichlorokynurenic acid
D-Serine
Cycloleucine
Milnacipran
CNS-5161
Acetylcysteine
Ketobemidone
Gavestinel
Agmatine
Ifenprodil
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Breast cancer (
29058716
)
Breast cancer (estrogen-receptor negative) (
29058716
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Household income (MTAG) (
31844048
)
Intelligence (MTAG) (
29326435
)
Lung function (FVC) (
24023788
)
Metabolite levels (
23823483
)
Obesity-related traits (
23251661
)
Optic disc size (
31809533
)
Periodontal disease-related phenotype (Socransky) (
24347629
)
PR interval (
32439900
)
Refractive error (
32231278
)
Response to hepatitis B vaccine (
29534301
)
Resting heart rate (
27798624
)
Temperament (bipolar disorder) (
22365631
)
Type 2 diabetes (
31049640
)
Urinary albumin-to-creatinine ratio in diabetes (
31511532
)
vWF and FVIII levels (
21810271
)
Interacting Genes
57 interacting genes:
ACTN2
AKAP9
APP
BDKRB1
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
PTAFR
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
23 interacting genes:
ARHGAP32
ARVCF
BOC
CDH11
CDH4
CDON
CREBBP
CTNNA1
CTNNB1
CTNND2
EXOC5
FGFR4
GNA12
GNA13
GRIK2
GRIN1
GRIN2D
JUP
LRRC7
PIK3R1
PKP4
PTPN1
UBC
Entrez ID
2902
1000
HPRD ID
15926
00226
Ensembl ID
ENSG00000176884
ENSG00000170558
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
A0A024RC42
C9J126
P19022
PDB IDs
2HQW
2NR1
3BYA
5H8F
5H8H
5H8N
5H8Q
5I2K
5I2N
5KCJ
5KDT
5TP9
5TPA
6IRA
6IRF
6IRG
6IRH
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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