PTAFR and SERINC5

Data Source:
BioGRID (two hybrid)

		PTAFR	SERINC5
Description		platelet activating factor receptor	serine incorporator 5
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Membrane Secretory Granule Membrane Tertiary Granule Membrane	Golgi Apparatus Centrosome Cytosol Plasma Membrane Membrane Integral Component Of Membrane Myelin Sheath Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Lipopolysaccharide Binding Lipopolysaccharide Immune Receptor Activity G Protein-coupled Receptor Activity Platelet Activating Factor Receptor Activity Protein Binding Phospholipid Binding G Protein-coupled Purinergic Nucleotide Receptor Activity Mitogen-activated Protein Kinase Binding
	Biological Process	Positive Regulation Of Cellular Extravasation Regulation Of Transcription By RNA Polymerase II Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Parturition Response To Symbiotic Bacterium Positive Regulation Of Phospholipase C Activity Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Transcytosis Positive Regulation Of Translation Negative Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Phosphatidylinositol-mediated Signaling Positive Regulation Of Smooth Muscle Cell Proliferation Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Inositol Phosphate Biosynthetic Process Cellular Response To Gravity Cellular Response To CAMP Cellular Response To Fatty Acid Response To Dexamethasone Positive Regulation Of Voltage-gated Chloride Channel Activity Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Sensory Perception Of Pain Positive Regulation Of Transcytosis Positive Regulation Of Maternal Process Involved In Parturition Positive Regulation Of Gastro-intestinal System Smooth Muscle Contraction Cellular Response To 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine	L-serine Biosynthetic Process Phosphatidylserine Metabolic Process Sphingolipid Metabolic Process Phospholipid Biosynthetic Process Detection Of Virus Viral Process Myelination Innate Immune Response Defense Response To Virus Positive Regulation Of CDP-diacylglycerol-serine O-phosphatidyltransferase Activity Positive Regulation Of Serine C-palmitoyltransferase Activity
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events Interleukin-10 signaling Neutrophil degranulation Interferon gamma signaling	Serine biosynthesis
Drugs		Platelet Activating Factor Etizolam Rupatadine
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825)	Alzheimer's disease in APOE e4- carriers ( 25778476) Borderline personality disorder features ( 23979607) Fasting blood glucose ( 28371326) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		19 interacting genes: ARR3 ARRB2 CALM1 GORAB GRIN1 GTPBP3 IFITM3 MBP MFSD3 PLLP PPM1J PRNP RGS4 RHBDD2 SERINC5 SPATA24 TMEM120A TMX2 TYK2	1 interacting genes: PTAFR
Entrez ID		5724	256987
HPRD ID		01422	12828
Ensembl ID		ENSG00000169403	ENSG00000164300
Uniprot IDs		A8K7N8 P25105	Q86VE9
PDB IDs		2B0X
Enriched GO Terms of Interacting Partners?
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