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GRIN1 and TUBA4B
Data Source:
HPRD
(in vivo)
GRIN1
TUBA4B
Description
glutamate ionotropic receptor NMDA type subunit 1
tubulin alpha 4b
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Dendrite
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Cellular_component
Cytoplasm
Microtubule
Molecular Function
Amyloid-beta Binding
NMDA Glutamate Receptor Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Ligand-gated Ion Channel Activity
Glycine Binding
Glutamate Binding
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Neurotransmitter Binding
Protein-containing Complex Binding
Molecular_function
GTPase Activity
Structural Constituent Of Cytoskeleton
GTP Binding
Biological Process
MAPK Cascade
Cation Transport
Chemical Synaptic Transmission
Brain Development
Visual Learning
Positive Regulation Of Calcium Ion Transport Into Cytosol
Propylene Metabolic Process
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Membrane Potential
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Ephrin Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Protein Heterotetramerization
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Response To Glycine
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Cysteine-type Endopeptidase Activity
Microtubule Cytoskeleton Organization
Mitotic Cell Cycle
Biological_process
Pathways
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Prasterone
5,7-Dichlorokynurenic acid
D-Serine
Cycloleucine
Milnacipran
CNS-5161
Acetylcysteine
Ketobemidone
Gavestinel
Agmatine
Ifenprodil
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Platelet distribution width (
27863252
)
Serum folate levels (
29953918
)
Interacting Genes
57 interacting genes:
ACTN2
AKAP9
APP
BDKRB1
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
PTAFR
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
1 interacting genes:
GRIN1
Entrez ID
2902
80086
HPRD ID
15926
18242
Ensembl ID
ENSG00000176884
ENSG00000243910
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
PDB IDs
2HQW
2NR1
3BYA
5H8F
5H8H
5H8N
5H8Q
5I2K
5I2N
5KCJ
5KDT
5TP9
5TPA
6IRA
6IRF
6IRG
6IRH
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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