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GRIN1 and DLG3
Data Source:
HPRD
(in vivo)
GRIN1
DLG3
Description
glutamate ionotropic receptor NMDA type subunit 1
discs large MAGUK scaffold protein 3
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Dendrite
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Extracellular Space
Cytosol
Plasma Membrane
Ionotropic Glutamate Receptor Complex
Basolateral Plasma Membrane
Cell Junction
Molecular Function
Amyloid-beta Binding
NMDA Glutamate Receptor Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Ligand-gated Ion Channel Activity
Glycine Binding
Glutamate Binding
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Neurotransmitter Binding
Protein-containing Complex Binding
Protein Binding
Kinase Binding
Phosphatase Binding
Biological Process
MAPK Cascade
Cation Transport
Chemical Synaptic Transmission
Brain Development
Visual Learning
Positive Regulation Of Calcium Ion Transport Into Cytosol
Propylene Metabolic Process
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Membrane Potential
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Ephrin Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Protein Heterotetramerization
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Response To Glycine
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Cysteine-type Endopeptidase Activity
MAPK Cascade
Negative Regulation Of Cell Population Proliferation
Embryo Development
Negative Regulation Of Phosphatase Activity
Receptor Clustering
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Positive Regulation Of Protein Tyrosine Kinase Activity
Receptor Localization To Synapse
Cell-cell Adhesion
Regulation Of NMDA Receptor Activity
Pathways
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
NrCAM interactions
Activation of Ca-permeable Kainate Receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Prasterone
5,7-Dichlorokynurenic acid
D-Serine
Cycloleucine
Milnacipran
CNS-5161
Acetylcysteine
Ketobemidone
Gavestinel
Agmatine
Ifenprodil
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
Non-syndromic X-linked mental retardation
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Mean platelet volume (
32888494
)
Interacting Genes
57 interacting genes:
ACTN2
AKAP9
APP
BDKRB1
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
PTAFR
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
48 interacting genes:
ABCA1
ADGRL1
APC
ATP2B4
CACNG2
CALM1
CNKSR2
CRIPT
DHRS11
DLG1
DLG4
DLGAP1
DLGAP2
DLGAP3
DLGAP4
EIF4H
ERBB4
EXOC4
EXOC7
GDA
GLS2
GRIK2
GRIN1
GRIN2A
GRIN2B
GRIN2C
GUCY1A2
KCNA4
KCNJ12
KCNJ2
KDELR1
KHDRBS1
KIF1B
LIN7A
LRP2
MAPK12
NLGN1
NLGN2
NLGN3
OSBP2
PLEKHA2
PTK2B
RPS8
SCN4A
SCN5A
SEMA4C
SYNGAP1
VTN
Entrez ID
2902
1741
HPRD ID
15926
02177
Ensembl ID
ENSG00000176884
ENSG00000082458
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
Q59FY1
Q92796
PDB IDs
2HQW
2NR1
3BYA
5H8F
5H8H
5H8N
5H8Q
5I2K
5I2N
5KCJ
5KDT
5TP9
5TPA
6IRA
6IRF
6IRG
6IRH
1UM7
2FE5
2I1N
Enriched GO Terms of Interacting Partners
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