GRIN1 and RPS6KA3

Data Source:
HPRD (in vivo)

		GRIN1	RPS6KA3
Description		glutamate ionotropic receptor NMDA type subunit 1	ribosomal protein S6 kinase A3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Synaptic Vesicle Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Dendrite Neuron Projection Synaptic Cleft Terminal Bouton Dendritic Spine Synapse Postsynaptic Membrane Excitatory Synapse Synaptic Membrane	Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Amyloid-beta Binding NMDA Glutamate Receptor Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Ligand-gated Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Neurotransmitter Binding Protein-containing Complex Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MAPK Cascade Cation Transport Chemical Synaptic Transmission Brain Development Visual Learning Positive Regulation Of Calcium Ion Transport Into Cytosol Propylene Metabolic Process Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Membrane Potential Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Protein Heterotetramerization Calcium Ion Homeostasis Excitatory Postsynaptic Potential Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Response To Glycine Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Cysteine-type Endopeptidase Activity	Skeletal System Development Toll-like Receptor Signaling Pathway Apoptotic Process Cell Cycle Signal Transduction Central Nervous System Development Peptidyl-serine Phosphorylation Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Translation In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Glutamic acid Tramadol Enflurane Atomoxetine Pentobarbital Methadone Secobarbital Meperidine Acamprosate Donepezil Guaifenesin Memantine Memantine Orphenadrine Phenobarbital Aripiprazole Prasterone 5,7-Dichlorokynurenic acid D-Serine Cycloleucine Milnacipran CNS-5161 Acetylcysteine Ketobemidone Gavestinel Agmatine Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Esketamine Fluciclovine (18F)	Acetylsalicylic acid Fostamatinib
Diseases			Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)	Refractive error ( 32231278)
Interacting Genes		57 interacting genes: ACTN2 AKAP9 APP BDKRB1 CALM1 CAMK2A CAMK2G CANX CDH2 CIT CLTC CTNNB1 DLG1 DLG2 DLG3 DLG4 DLGAP4 DNM1 DRD1 DUSP4 EPHB2 EPHB4 FUS FYN GRIN2A GRIN2B GRIN2D GRIN3A HNRNPU HRAS HSPA1A INA LNX1 LRP8 MAP2 MAP2K2 MYH9 NANOS1 NEFL NF1 PLAT PLCG1 PPP2R1A PPP2R2A PRKCA PRKCB PRKCE PRKCG PTAFR RAP2A RPS6KA3 SP3 SPTAN1 SYNGAP1 TJP1 TRAF3 TUBA4B	40 interacting genes: ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR1 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 NEDD4 NFKBIA NR4A1 PDPK1 PEA15 SHANK1 SMS SRC STK11 SUMO2 TP53 YBX1
Entrez ID		2902	6197
HPRD ID		15926	02092
Ensembl ID		ENSG00000176884	ENSG00000177189
Uniprot IDs		Q05586 Q59GW0 Q5VSF9	A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812
PDB IDs		2HQW 2NR1 3BYA 5H8F 5H8H 5H8N 5H8Q 5I2K 5I2N 5KCJ 5KDT 5TP9 5TPA 6IRA 6IRF 6IRG 6IRH	4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L
Enriched GO Terms of Interacting Partners?
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