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GRIN1 and EPHB2
Data Source:
HPRD
(in vitro)
GRIN1
EPHB2
Description
glutamate ionotropic receptor NMDA type subunit 1
EPH receptor B2
Image
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Dendrite
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Extracellular Region
Nucleoplasm
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Axon
Dendrite
Neuron Projection
Neuronal Cell Body
Receptor Complex
Postsynapse
Glutamatergic Synapse
Integral Component Of Postsynaptic Membrane
Integral Component Of Presynaptic Membrane
Molecular Function
Amyloid-beta Binding
NMDA Glutamate Receptor Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Ligand-gated Ion Channel Activity
Glycine Binding
Glutamate Binding
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Neurotransmitter Binding
Protein-containing Complex Binding
Amyloid-beta Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane-ephrin Receptor Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Axon Guidance Receptor Activity
Identical Protein Binding
Protein-containing Complex Binding
Biological Process
MAPK Cascade
Cation Transport
Chemical Synaptic Transmission
Brain Development
Visual Learning
Positive Regulation Of Calcium Ion Transport Into Cytosol
Propylene Metabolic Process
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Membrane Potential
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Ephrin Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Protein Heterotetramerization
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Response To Glycine
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Cysteine-type Endopeptidase Activity
Angiogenesis
Urogenital System Development
Negative Regulation Of Protein Phosphorylation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Nervous System Development
Axon Guidance
Axonal Fasciculation
Learning Or Memory
Learning
Positive Regulation Of Gene Expression
Phosphorylation
Peptidyl-tyrosine Phosphorylation
Optic Nerve Morphogenesis
Central Nervous System Projection Neuron Axonogenesis
Corpus Callosum Development
Regulation Of Blood Coagulation
Retinal Ganglion Cell Axon Guidance
Positive Regulation Of Synaptic Plasticity
Positive Regulation Of Kinase Activity
Inner Ear Morphogenesis
Negative Regulation Of Ras Protein Signal Transduction
Ephrin Receptor Signaling Pathway
Regulation Of Neuronal Synaptic Plasticity
Positive Regulation Of Long-term Neuronal Synaptic Plasticity
Camera-type Eye Morphogenesis
Negative Regulation Of Axonogenesis
Regulation Of Body Fluid Levels
Inactivation Of MAPKK Activity
Positive Regulation Of Synapse Assembly
Roof Of Mouth Development
Dendritic Spine Development
Dendritic Spine Morphogenesis
Negative Regulation Of ERK1 And ERK2 Cascade
Commissural Neuron Axon Guidance
Postsynaptic Membrane Assembly
Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission
Neuron Projection Retraction
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Negative Regulation Of NMDA Glutamate Receptor Activity
Positive Regulation Of NMDA Glutamate Receptor Activity
Pathways
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
EPH-Ephrin signaling
EPH-Ephrin signaling
L1CAM interactions
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Ephrin signaling
Ephrin signaling
EPH-ephrin mediated repulsion of cells
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Prasterone
5,7-Dichlorokynurenic acid
D-Serine
Cycloleucine
Milnacipran
CNS-5161
Acetylcysteine
Ketobemidone
Gavestinel
Agmatine
Ifenprodil
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Phosphoaminophosphonic Acid-Adenylate Ester
Fostamatinib
Diseases
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Blood protein levels (
30072576
29875488
28240269
)
Refractive error (
32231278
)
Triiodothyronine levels (
30843173
)
Triiodothyronine levels and thyroxine levels (
30843173
)
Interacting Genes
57 interacting genes:
ACTN2
AKAP9
APP
BDKRB1
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
PTAFR
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
39 interacting genes:
ABL1
ABL2
ACP1
AFDN
AQP1
ARHGEF6
CRK
EFNA5
EFNB1
EFNB2
ERBB2
ERF
FBXO7
FOS
GRB2
GRIN1
GRIN2B
ITSN1
KALRN
KSR1
MMP2
MMP9
MTMR14
NCK1
PICK1
PLCG1
PTK2
RASA1
RRAS
RYK
SDC2
SDCBP
SH2D3C
SRC
SYNJ1
TRIM54
VAV2
VEGFA
YES1
Entrez ID
2902
2048
HPRD ID
15926
02997
Ensembl ID
ENSG00000176884
ENSG00000133216
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
B4DSE0
P29323
Q4LE53
Q6NVW1
PDB IDs
2HQW
2NR1
3BYA
5H8F
5H8H
5H8N
5H8Q
5I2K
5I2N
5KCJ
5KDT
5TP9
5TPA
6IRA
6IRF
6IRG
6IRH
1B4F
1F0M
2QBX
3ZFM
Enriched GO Terms of Interacting Partners
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