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GRIN1 and SYNGAP1
Data Source:
HPRD
(in vivo)
GRIN1
SYNGAP1
Description
glutamate ionotropic receptor NMDA type subunit 1
synaptic Ras GTPase activating protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Synaptic Vesicle
Cell Surface
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Dendrite
Neuron Projection
Synaptic Cleft
Terminal Bouton
Dendritic Spine
Synapse
Postsynaptic Membrane
Excitatory Synapse
Synaptic Membrane
Cytosol
Plasma Membrane
Postsynaptic Density
Dendritic Shaft
Glutamatergic Synapse
Molecular Function
Amyloid-beta Binding
NMDA Glutamate Receptor Activity
Calcium Channel Activity
Calcium Ion Binding
Protein Binding
Calmodulin Binding
Ligand-gated Ion Channel Activity
Glycine Binding
Glutamate Binding
Glutamate-gated Calcium Ion Channel Activity
Signaling Receptor Activity
Neurotransmitter Binding
Protein-containing Complex Binding
GTPase Activator Activity
Protein Binding
SH3 Domain Binding
Biological Process
MAPK Cascade
Cation Transport
Chemical Synaptic Transmission
Brain Development
Visual Learning
Positive Regulation Of Calcium Ion Transport Into Cytosol
Propylene Metabolic Process
Calcium-mediated Signaling
Ionotropic Glutamate Receptor Signaling Pathway
Regulation Of Membrane Potential
Response To Ethanol
Positive Regulation Of Transcription By RNA Polymerase II
Ephrin Receptor Signaling Pathway
Regulation Of Synaptic Plasticity
Protein Heterotetramerization
Calcium Ion Homeostasis
Excitatory Postsynaptic Potential
Calcium Ion Transmembrane Import Into Cytosol
Excitatory Chemical Synaptic Transmission
Positive Regulation Of Reactive Oxygen Species Biosynthetic Process
Cellular Response To Amyloid-beta
Response To Glycine
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of Cysteine-type Endopeptidase Activity
MAPK Cascade
Ras Protein Signal Transduction
Pattern Specification Process
Visual Learning
Dendrite Development
Receptor Clustering
Regulation Of MAPK Cascade
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of GTPase Activity
Negative Regulation Of Ras Protein Signal Transduction
Regulation Of Synaptic Plasticity
Regulation Of Long-term Neuronal Synaptic Plasticity
Negative Regulation Of Axonogenesis
Regulation Of Synapse Structure Or Activity
Maintenance Of Postsynaptic Specialization Structure
Pathways
EPHB-mediated forward signaling
EPHB-mediated forward signaling
Unblocking of NMDA receptors, glutamate binding and activation
Unblocking of NMDA receptors, glutamate binding and activation
Ras activation upon Ca2+ influx through NMDA receptor
RAF/MAP kinase cascade
Neurexins and neuroligins
Synaptic adhesion-like molecules
Assembly and cell surface presentation of NMDA receptors
Assembly and cell surface presentation of NMDA receptors
Negative regulation of NMDA receptor-mediated neuronal transmission
Long-term potentiation
Regulation of RAS by GAPs
Drugs
Glutamic acid
Tramadol
Enflurane
Atomoxetine
Pentobarbital
Methadone
Secobarbital
Meperidine
Acamprosate
Donepezil
Guaifenesin
Memantine
Memantine
Orphenadrine
Phenobarbital
Aripiprazole
Prasterone
5,7-Dichlorokynurenic acid
D-Serine
Cycloleucine
Milnacipran
CNS-5161
Acetylcysteine
Ketobemidone
Gavestinel
Agmatine
Ifenprodil
Magnesium acetate tetrahydrate
Magnesium carbonate
Esketamine
Fluciclovine (18F)
Diseases
Non-syndromic autosomal dominant mental retardation
GWAS
Post-traumatic stress disorder (asjusted for relatedness) (
23726511
)
Autism spectrum disorder or schizophrenia (
28540026
)
Body mass index (
26426971
)
Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) (
30940143
)
Late-onset Alzheimer's disease (
27770636
)
Schizophrenia (
30285260
)
Interacting Genes
57 interacting genes:
ACTN2
AKAP9
APP
BDKRB1
CALM1
CAMK2A
CAMK2G
CANX
CDH2
CIT
CLTC
CTNNB1
DLG1
DLG2
DLG3
DLG4
DLGAP4
DNM1
DRD1
DUSP4
EPHB2
EPHB4
FUS
FYN
GRIN2A
GRIN2B
GRIN2D
GRIN3A
HNRNPU
HRAS
HSPA1A
INA
LNX1
LRP8
MAP2
MAP2K2
MYH9
NANOS1
NEFL
NF1
PLAT
PLCG1
PPP2R1A
PPP2R2A
PRKCA
PRKCB
PRKCE
PRKCG
PTAFR
RAP2A
RPS6KA3
SP3
SPTAN1
SYNGAP1
TJP1
TRAF3
TUBA4B
28 interacting genes:
CAMK2A
DLG3
DLG4
DLGAP4
EFHC1
GRIN1
GRIN2B
GRIN2D
GUCD1
HSF2BP
KDR
MGAT5B
MID2
MKRN3
MPDZ
NCK2
NTAQ1
OSTF1
PDGFRB
SPAG8
SUOX
TLX3
TRIM27
TRIP6
TSSK3
ULK1
ULK2
VENTX
Entrez ID
2902
8831
HPRD ID
15926
16018
Ensembl ID
ENSG00000176884
ENSG00000197283
Uniprot IDs
Q05586
Q59GW0
Q5VSF9
A0A1U9X8L0
B7ZCA0
Q96PV0
PDB IDs
2HQW
2NR1
3BYA
5H8F
5H8H
5H8N
5H8Q
5I2K
5I2N
5KCJ
5KDT
5TP9
5TPA
6IRA
6IRF
6IRG
6IRH
Enriched GO Terms of Interacting Partners
?
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Tagcloud (Difference)
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Tagcloud (Intersection)
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