WRNIP1 and TRIM14

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		WRNIP1	TRIM14
Description		WRN helicase interacting protein 1	tripartite motif containing 14
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Cytosol Phagocytic Vesicle
	Molecular Function	DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATPase Activity Single-stranded DNA Helicase Activity Identical Protein Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity
	Biological Process	DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Regulation Of DNA Repair Regulation Of DNA-dependent DNA Replication Initiation DNA Duplex Unwinding Innate Immune Response Regulation Of Catalytic Activity	Protein Polyubiquitination Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Regulation Of Protein Localization Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Plateletcrit ( 32888494)	Multiple sclerosis ( 31604244)
Interacting Genes		12 interacting genes: ABL1 ERBB3 PCNA PIK3R3 PIN1 POLD1 POLD2 POLD4 TOLLIP TRIM14 UBC WRN	84 interacting genes: ABCF3 ADAMTS12 ALG13 AP3M1 ATP1B1 ATP1B3 ATP2A2 ATP5PB ATP6V1H BYSL CARD9 CCDC125 CCDC57 CCDC6 CENPC CIB3 CKS1B CSPP1 EIF3G ERCC3 ETFBKMT EXOC8 FAM50B FAT1 GOLGA2 GOLGA6L9 HERC3 HEXIM2 HNRNPF IHO1 ITM2A IVNS1ABP KAT2B KIF3A KIFC3 LAMTOR1 LNX1 MAPRE3 MITD1 MNAT1 MRPL24 MYO15B NCOR1 NDUFA9 NFAT5 NPC2 PCGF6 PDIA6 PHF11 PIM2 PLCG1 POLR1C POLR2G PPP2R3C PRDM6 PRKAB2 PRPF31 PTPN21 RAB5A RAB9A RAD51D RBM33 RLF RNF125 RNF20 SLF2 SMARCB1 SMIM3 SPG21 STK38 TAX1BP1 TMEM167A TRAF2 TSGA10 UBE2B UBE2N UNK VIM WDR35 WRNIP1 ZC4H2 ZFP36L2 ZGPAT ZNF652
Entrez ID		56897	9830
HPRD ID		10494	05948
Ensembl ID		ENSG00000124535	ENSG00000106785
Uniprot IDs		Q96S55	A0A024R165 Q14142
PDB IDs		3VHS 3VHT	6JBM
Enriched GO Terms of Interacting Partners?
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