WRNIP1 and POLD4

Data Source:
HPRD (in vitro)

		WRNIP1	POLD4
Description		WRN helicase interacting protein 1	DNA polymerase delta 4, accessory subunit
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Membrane Perinuclear Region Of Cytoplasm	Nucleoplasm Delta DNA Polymerase Complex
	Molecular Function	DNA Binding Protein Binding ATP Binding Enzyme Activator Activity ATPase Activity Single-stranded DNA Helicase Activity Identical Protein Binding Metal Ion Binding	DNA-directed DNA Polymerase Activity Protein Binding
	Biological Process	DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Regulation Of DNA Repair Regulation Of DNA-dependent DNA Replication Initiation DNA Duplex Unwinding Innate Immune Response Regulation Of Catalytic Activity	Telomere Maintenance DNA Synthesis Involved In DNA Repair DNA-dependent DNA Replication Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Translesion Synthesis Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision DNA Damage Response, Detection Of DNA Damage
Pathways			Recognition of DNA damage by PCNA-containing replication complex Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Removal of the Flap Intermediate from the C-strand Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand
Drugs
Diseases
GWAS		Plateletcrit ( 32888494)	Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)
Interacting Genes		12 interacting genes: ABL1 ERBB3 PCNA PIK3R3 PIN1 POLD1 POLD2 POLD4 TOLLIP TRIM14 UBC WRN	9 interacting genes: DTL PCNA POLD1 POLD2 POLD3 POLE RNF8 SEC23IP WRNIP1
Entrez ID		56897	57804
HPRD ID		10494	17873
Ensembl ID		ENSG00000124535	ENSG00000175482
Uniprot IDs		Q96S55	A0A024R5D7 Q6NSD7 Q9HCU8
PDB IDs		3VHS 3VHT	6HVO 6S1M 6S1N 6S1O 6TNY 6TNZ
Enriched GO Terms of Interacting Partners?
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