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PRKAA2 and SPRY1
Data Source:
BioGRID
(two hybrid)
PRKAA2
SPRY1
Description
protein kinase AMP-activated catalytic subunit alpha 2
sprouty RTK signaling antagonist 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Cytoplasmic Stress Granule
Nuclear Speck
Axon
Dendrite
Neuronal Cell Body
Nucleoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Molecular Function
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Biological Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Carnitine Shuttle
Cell Cycle Arrest
Signal Transduction
Lipid Biosynthetic Process
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Response To Muscle Activity
Wnt Signaling Pathway
Macroautophagy
Positive Regulation Of Macroautophagy
Regulation Of Macroautophagy
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Cellular Response To Oxidative Stress
Histone-serine Phosphorylation
Intracellular Signal Transduction
Cellular Response To Drug
Cellular Response To Glucose Starvation
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Glycolytic Process
Rhythmic Process
Fatty Acid Homeostasis
Regulation Of Stress Granule Assembly
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Prostaglandin E Stimulus
Energy Homeostasis
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Cellular Protein Localization
Negative Regulation Of Tubulin Deacetylation
Positive Regulation Of Peptidyl-lysine Acetylation
Establishment Of Mitotic Spindle Orientation
Metanephros Development
Ureteric Bud Development
Organ Induction
Negative Regulation Of Cell Population Proliferation
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of GTPase Activity
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Bud Elongation Involved In Lung Branching
Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Lens Fiber Cell Differentiation
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
EGFR downregulation
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Lymphocyte counts (
22286170
)
Apolipoprotein B levels (
32203549
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) (
29455858
)
Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) (
29455858
)
Irritable bowel syndrome (
24797007
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) (
30698716
)
Metabolite levels (
23823483
)
Pelvic organ prolapse (
26545240
)
Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) (
29455858
)
Triglyceride levels (
32203549
)
Interacting Genes
122 interacting genes:
ABI1
ABI2
ACACA
ACACB
AIMP2
AKAP8L
AMOT
AMOTL2
ANAPC11
APPBP2
ARRDC3
AVPI1
C19orf47
CALCOCO1
CALCOCO2
CCDC172
CCDC33
CCNB1IP1
CDC42EP1
CDR2
CDX4
CPSF7
CTAG2
CYSRT1
DNAAF6
DNM2
DNMT1
DVL3
EEF2K
EMILIN1
EPM2A
EPN2
FNDC3B
FOS
GIGYF1
GLI1
GOLGA2
GOLGA6A
GRAP2
HAT1
HMBOX1
HNF4A
HOMEZ
IKZF1
IKZF3
KCTD1
KCTD9
KIAA1328
KIF16B
KIF24
KIFC3
KRT16
KRT31
KRTAP1-3
KRTAP10-3
KRTAP10-9
L3MBTL3
LCN2
LEP
LZTS2
MKRN3
MORN3
MRFAP1
MTUS2
MYCL
MYOZ1
NAB2
NECAB2
NONO
NOTCH2NLA
NRAP
NRBF2
NUTM1
PBXIP1
PFKFB2
PLEKHN1
PPP1R32
PRDM6
PRKAB1
PRKAG1
PRKAR1B
PRKN
PRPH
RASAL3
RBBP7
RBPMS
REL
RFX6
RPTOR
SERTAD3
SKIV2L
SLA2
SNW1
SOHLH1
SPRY1
STAC2
STK11
TCF4
TFAP2A
TIFA
TLE5
TMOD1
TRIP13
TRIP6
TSC22D4
UBE2I
USH1C
USH1G
USHBP1
USP10
VPS28
VPS37B
VPS52
WASHC1
WWP1
WWP2
YPEL3
ZBTB8A
ZMYND12
ZNF212
ZNF397
ZSCAN23
83 interacting genes:
ADAM12
ADAMTSL4
ANKRD11
ATXN7
CACNA1A
CCDC57
CDR2L
CHRD
CREB5
CYSRT1
FARS2
FBLN1
FHL5
GEMIN4
GNE
GRB2
GUCD1
HEXIM2
HOXA1
HRG
HSF2BP
INCA1
KPNA2
KPRP
KRT31
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-2
KRTAP12-3
KRTAP3-2
KRTAP4-12
KRTAP4-2
KRTAP5-9
KRTAP9-2
KRTAP9-3
LCE1A
LCE1B
LCE1C
LCE1D
LCE1F
LCE2A
LCE2C
LCE2D
LCE3A
LCE3C
LCE3D
LCE4A
LCE5A
MB21D2
MDFI
MEOX2
NBPF19
NOTCH2NLA
NTM
OTX1
PCSK5
POLR1C
PRKAA2
PRKAB2
R3HDM2
REL
SMCP
SOCS4
SPRY2
STAT3
TFAP2D
TGM7
UBASH3A
VWC2
YY1
ZNF23
ZNF330
ZNF417
ZNF441
ZNF837
Entrez ID
5563
10252
HPRD ID
02735
06782
Ensembl ID
ENSG00000162409
ENSG00000164056
Uniprot IDs
P54646
O43609
PDB IDs
2H6D
2LTU
2YZA
3AQV
4CFE
4CFF
4ZHX
5EZV
5ISO
6B1U
6B2E
6BX6
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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