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PRKAA2 and VPS52
Data Source:
BioGRID
(two hybrid)
PRKAA2
VPS52
Description
protein kinase AMP-activated catalytic subunit alpha 2
VPS52 subunit of GARP complex
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Cytoplasmic Stress Granule
Nuclear Speck
Axon
Dendrite
Neuronal Cell Body
GARP Complex
Golgi Apparatus
Cytosol
Endosome Membrane
Membrane
Trans-Golgi Network Membrane
Perinuclear Region Of Cytoplasm
Recycling Endosome
EARP Complex
Molecular Function
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Protein Binding
Syntaxin Binding
Biological Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Carnitine Shuttle
Cell Cycle Arrest
Signal Transduction
Lipid Biosynthetic Process
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Response To Muscle Activity
Wnt Signaling Pathway
Macroautophagy
Positive Regulation Of Macroautophagy
Regulation Of Macroautophagy
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Cellular Response To Oxidative Stress
Histone-serine Phosphorylation
Intracellular Signal Transduction
Cellular Response To Drug
Cellular Response To Glucose Starvation
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Glycolytic Process
Rhythmic Process
Fatty Acid Homeostasis
Regulation Of Stress Granule Assembly
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Prostaglandin E Stimulus
Energy Homeostasis
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Cellular Protein Localization
Negative Regulation Of Tubulin Deacetylation
Positive Regulation Of Peptidyl-lysine Acetylation
Golgi To Vacuole Transport
Lysosomal Transport
Ectodermal Cell Differentiation
Protein Transport
Endocytic Recycling
Retrograde Transport, Endosome To Golgi
Embryonic Ectodermal Digestive Tract Development
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
Retrograde transport at the Trans-Golgi-Network
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Lymphocyte counts (
22286170
)
Autism spectrum disorder or schizophrenia (
28540026
)
Body mass index (
26426971
)
Interacting Genes
122 interacting genes:
ABI1
ABI2
ACACA
ACACB
AIMP2
AKAP8L
AMOT
AMOTL2
ANAPC11
APPBP2
ARRDC3
AVPI1
C19orf47
CALCOCO1
CALCOCO2
CCDC172
CCDC33
CCNB1IP1
CDC42EP1
CDR2
CDX4
CPSF7
CTAG2
CYSRT1
DNAAF6
DNM2
DNMT1
DVL3
EEF2K
EMILIN1
EPM2A
EPN2
FNDC3B
FOS
GIGYF1
GLI1
GOLGA2
GOLGA6A
GRAP2
HAT1
HMBOX1
HNF4A
HOMEZ
IKZF1
IKZF3
KCTD1
KCTD9
KIAA1328
KIF16B
KIF24
KIFC3
KRT16
KRT31
KRTAP1-3
KRTAP10-3
KRTAP10-9
L3MBTL3
LCN2
LEP
LZTS2
MKRN3
MORN3
MRFAP1
MTUS2
MYCL
MYOZ1
NAB2
NECAB2
NONO
NOTCH2NLA
NRAP
NRBF2
NUTM1
PBXIP1
PFKFB2
PLEKHN1
PPP1R32
PRDM6
PRKAB1
PRKAG1
PRKAR1B
PRKN
PRPH
RASAL3
RBBP7
RBPMS
REL
RFX6
RPTOR
SERTAD3
SKIV2L
SLA2
SNW1
SOHLH1
SPRY1
STAC2
STK11
TCF4
TFAP2A
TIFA
TLE5
TMOD1
TRIP13
TRIP6
TSC22D4
UBE2I
USH1C
USH1G
USHBP1
USP10
VPS28
VPS37B
VPS52
WASHC1
WWP1
WWP2
YPEL3
ZBTB8A
ZMYND12
ZNF212
ZNF397
ZSCAN23
104 interacting genes:
AAMP
ARNT2
ATP6V1D
BORCS6
BYSL
C1orf109
C1orf216
C2CD6
CABP5
CACNA1A
CCDC102B
CCDC13
CCDC146
CCDC185
CCDC187
CCDC33
CCDC57
CCHCR1
CDC20B
CDC5L
CDK18
CEP19
CFAP206
CWF19L2
DCX
DDX6
DNAJC11
DTNB
EEF1AKNMT
EPM2AIP1
FAM110A
FAM161A
FAM161B
FAM184A
FAM50B
GEM
GFM2
GOLGA1
GORASP2
GPKOW
HAUS1
HDAC4
HEATR1
HGS
HOXB5
JAKMIP2
KANK2
KIAA1217
KIF5B
KIF9
KIFC3
KLC3
KLHL42
LMO4
LNX1
MAGEL2
MAPK3
MFAP1
MRPL1
MRPL11
NDC80
NFKBIB
NOP2
NR2C2AP
OTUD6A
PIMREG
PKN3
PPP1R18
PRKAA1
PRKAA2
RAB4A
RAB4B
RABEP2
RNF41
RUNX1T1
SCNM1
SH2D4A
SMARCE1
STX11
TAB2
TBC1D1
TBC1D22B
TCEANC
TCP11L1
TEAD4
THAP11
TPM3
TRAF4
TRAF6
TSSK3
TSTD2
TXLNA
TXLNB
TXN2
USP2
VEZF1
VPS28
VPS53
WASHC3
WTAP
ZC2HC1C
ZMAT2
ZNF417
ZNF587
Entrez ID
5563
6293
HPRD ID
02735
09142
Ensembl ID
ENSG00000162409
ENSG00000223501
Uniprot IDs
P54646
A0A1U9X8S4
B3KMF7
B4DS44
Q4VXZ2
Q8N1B4
PDB IDs
2H6D
2LTU
2YZA
3AQV
4CFE
4CFF
4ZHX
5EZV
5ISO
6B1U
6B2E
6BX6
Enriched GO Terms of Interacting Partners
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