Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PRKAA2 and LEP
Data Source:
HPRD
(in vitro)
PRKAA2
LEP
Description
protein kinase AMP-activated catalytic subunit alpha 2
leptin
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Cytoplasmic Stress Granule
Nuclear Speck
Axon
Dendrite
Neuronal Cell Body
Extracellular Region
Extracellular Space
Cytosol
Molecular Function
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
DNA Binding
Hormone Activity
Protein Binding
Peptide Hormone Receptor Binding
Leptin Receptor Binding
Biological Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Carnitine Shuttle
Cell Cycle Arrest
Signal Transduction
Lipid Biosynthetic Process
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Response To Muscle Activity
Wnt Signaling Pathway
Macroautophagy
Positive Regulation Of Macroautophagy
Regulation Of Macroautophagy
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Cellular Response To Oxidative Stress
Histone-serine Phosphorylation
Intracellular Signal Transduction
Cellular Response To Drug
Cellular Response To Glucose Starvation
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Glycolytic Process
Rhythmic Process
Fatty Acid Homeostasis
Regulation Of Stress Granule Assembly
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Prostaglandin E Stimulus
Energy Homeostasis
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Cellular Protein Localization
Negative Regulation Of Tubulin Deacetylation
Positive Regulation Of Peptidyl-lysine Acetylation
Negative Regulation Of Transcription By RNA Polymerase II
Angiogenesis
Ovulation From Ovarian Follicle
Response To Hypoxia
Placenta Development
Positive Regulation Of Protein Phosphorylation
Regulation Of Endothelial Cell Proliferation
Response To Dietary Excess
Cardiac Muscle Hypertrophy
Glucose Metabolic Process
Regulation Of Gluconeogenesis
Energy Reserve Metabolic Process
Glycerol Biosynthetic Process
Lipid Metabolic Process
Fatty Acid Beta-oxidation
Phagocytosis
Tyrosine Phosphorylation Of STAT Protein
Female Pregnancy
Circadian Rhythm
Cholesterol Metabolic Process
Bile Acid Metabolic Process
Regulation Of Blood Pressure
Determination Of Adult Lifespan
Adult Feeding Behavior
Negative Regulation Of Autophagy
Negative Regulation Of Lipid Storage
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Response To Activity
Sexual Reproduction
Central Nervous System Neuron Development
Insulin Secretion
T Cell Differentiation
Regulation Of Intestinal Cholesterol Absorption
Positive Regulation Of TOR Signaling
Negative Regulation Of Appetite
Prostaglandin Secretion
Response To Estradiol
Interleukin-6 Production
Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Regulation Of Natural Killer Cell Activation
Regulation Of Natural Killer Cell Proliferation
Response To Insulin
Cellular Response To Insulin Stimulus
Response To Vitamin E
Leptin-mediated Signaling Pathway
Positive Regulation Of Luteinizing Hormone Secretion
Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway
Intracellular Signal Transduction
Bone Mineralization Involved In Bone Maturation
Aorta Development
Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway
Positive Regulation Of T Cell Proliferation
Regulation Of Natural Killer Cell Mediated Cytotoxicity
Positive Regulation Of Protein Import Into Nucleus
Hormone Metabolic Process
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Eating Behavior
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Cellular Response To Leptin Stimulus
Response To Ethanol
Regulation Of Angiogenesis
Negative Regulation Of Vasoconstriction
Negative Regulation Of Glucose Import
Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT
Positive Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Bone Remodeling
Positive Regulation Of Follicle-stimulating Hormone Secretion
Positive Regulation Of Developmental Growth
Regulation Of Insulin Secretion
Regulation Of Steroid Biosynthetic Process
Intestinal Absorption
Leukocyte Tethering Or Rolling
Regulation Of Nitric-oxide Synthase Activity
Elastin Metabolic Process
Regulation Of Cell Cycle
Positive Regulation Of Protein Kinase B Signaling
Regulation Of Lipoprotein Lipid Oxidation
Adipose Tissue Development
Negative Regulation Of Cartilage Development
Negative Regulation Of Glucagon Secretion
Cellular Response To L-ascorbic Acid
Cellular Response To Retinoic Acid
Regulation Of Brown Fat Cell Differentiation
Bone Growth
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of P38MAPK Cascade
Positive Regulation Of Fat Cell Apoptotic Process
Activation Of Protein Kinase C Activity
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Glutamine Transport
Positive Regulation Of Hepatic Stellate Cell Activation
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
Signaling by Leptin
Transcriptional regulation of white adipocyte differentiation
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Synthesis, secretion, and deacylation of Ghrelin
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Lymphocyte counts (
22286170
)
BMI at 1.5 years old (
31575865
)
BMI at 8 months old (
31575865
)
Body size at age 10 (
32376654
)
circulating leptin levels (
32917775
26833098
)
circulating leptin levels adjusted for BMI (
32917775
26833098
)
High density lipoprotein cholesterol levels (
29403010
)
Type 2 diabetes (
26818947
23945395
32499647
)
Interacting Genes
122 interacting genes:
ABI1
ABI2
ACACA
ACACB
AIMP2
AKAP8L
AMOT
AMOTL2
ANAPC11
APPBP2
ARRDC3
AVPI1
C19orf47
CALCOCO1
CALCOCO2
CCDC172
CCDC33
CCNB1IP1
CDC42EP1
CDR2
CDX4
CPSF7
CTAG2
CYSRT1
DNAAF6
DNM2
DNMT1
DVL3
EEF2K
EMILIN1
EPM2A
EPN2
FNDC3B
FOS
GIGYF1
GLI1
GOLGA2
GOLGA6A
GRAP2
HAT1
HMBOX1
HNF4A
HOMEZ
IKZF1
IKZF3
KCTD1
KCTD9
KIAA1328
KIF16B
KIF24
KIFC3
KRT16
KRT31
KRTAP1-3
KRTAP10-3
KRTAP10-9
L3MBTL3
LCN2
LEP
LZTS2
MKRN3
MORN3
MRFAP1
MTUS2
MYCL
MYOZ1
NAB2
NECAB2
NONO
NOTCH2NLA
NRAP
NRBF2
NUTM1
PBXIP1
PFKFB2
PLEKHN1
PPP1R32
PRDM6
PRKAB1
PRKAG1
PRKAR1B
PRKN
PRPH
RASAL3
RBBP7
RBPMS
REL
RFX6
RPTOR
SERTAD3
SKIV2L
SLA2
SNW1
SOHLH1
SPRY1
STAC2
STK11
TCF4
TFAP2A
TIFA
TLE5
TMOD1
TRIP13
TRIP6
TSC22D4
UBE2I
USH1C
USH1G
USHBP1
USP10
VPS28
VPS37B
VPS52
WASHC1
WWP1
WWP2
YPEL3
ZBTB8A
ZMYND12
ZNF212
ZNF397
ZSCAN23
10 interacting genes:
A2M
CLU
CRP
GHRL
HK3
HSF2BP
LEPR
PRKAA2
SIGLEC6
UCN
Entrez ID
5563
3952
HPRD ID
02735
01249
Ensembl ID
ENSG00000162409
ENSG00000174697
Uniprot IDs
P54646
A4D0Y8
P41159
PDB IDs
2H6D
2LTU
2YZA
3AQV
4CFE
4CFF
4ZHX
5EZV
5ISO
6B1U
6B2E
6BX6
1AX8
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?