SPRY1 and CCDC57

Data Source:
BioGRID (two hybrid)

		SPRY1	CCDC57
Description		sprouty RTK signaling antagonist 1	coiled-coil domain containing 57
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane	Centrosome Centriole Spindle Microtubule Centriolar Satellite
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Population Proliferation Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Lens Fiber Cell Differentiation	G2/M Transition Of Mitotic Cell Cycle Microtubule Nucleation Centriole Replication Positive Regulation Of Mitotic Cell Cycle Cilium Assembly
Pathways		EGFR downregulation
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Triglyceride levels ( 32203549)	Blood metabolite levels ( 24816252) Blood urea nitrogen levels ( 31152163) Proteinuria and chronic kidney disease ( 26420894) Refractive error ( 32231278)
Interacting Genes		83 interacting genes: ADAM12 ADAMTSL4 ANKRD11 ATXN7 CACNA1A CCDC57 CDR2L CHRD CREB5 CYSRT1 FARS2 FBLN1 FHL5 GEMIN4 GNE GRB2 GUCD1 HEXIM2 HOXA1 HRG HSF2BP INCA1 KPNA2 KPRP KRT31 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-2 KRTAP12-3 KRTAP3-2 KRTAP4-12 KRTAP4-2 KRTAP5-9 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1F LCE2A LCE2C LCE2D LCE3A LCE3C LCE3D LCE4A LCE5A MB21D2 MDFI MEOX2 NBPF19 NOTCH2NLA NTM OTX1 PCSK5 POLR1C PRKAA2 PRKAB2 R3HDM2 REL SMCP SOCS4 SPRY2 STAT3 TFAP2D TGM7 UBASH3A VWC2 YY1 ZNF23 ZNF330 ZNF417 ZNF441 ZNF837	148 interacting genes: ABI1 ABI2 ABLIM1 AMOTL2 ANKRD23 AQP1 ARID5A ARL4A AXIN1 BCAR3 BEX2 C19orf44 C2CD6 C4orf45 C9orf24 CBX8 CBY2 CCDC120 CCDC33 CDC20B CEP57L1 CFAP53 COIL CRTC2 CWF19L2 DCLK2 DISC1 DTX2 ECPAS EFHC2 EIF3D EIF4G1 ELOA EMILIN3 ESS2 FAM107A FAM161A FAM161B FAM228A FAM50B FAM90A1 FH FOXD4L1 FTO GFAP GIGYF1 GPBP1 GPKOW GRPEL1 HAUS1 HBA2 HDX IHO1 IKZF3 INCA1 INTS2 JRK KANK2 KIAA0408 KLF1 KLF15 KPRP KRT4 KRT76 KRTAP13-2 KRTAP13-3 LENG1 LINC00526 LZTS1 MAD1L1 MDM1 MFAP1 MT1E MYOZ3 NAB2 NAPRT NCOA5 NELFE NME4 NUMA1 PAK5 PER1 POM121 PPHLN1 PPP1R18 PPP1R32 PRAM1 PRDM6 PROSER3 PRPF18 PRPF31 PRR3 PSMB4 PTCHD3 PTPN7 RAB3IL1 RASD1 RBM48 RDM1 RINT1 RNF6 ROBO3 RUSC1 RXRB SFI1 SH3KBP1 SHISA6 SIRPA SLC25A48 SMG9 SNRNP35 SORBS3 SPRY1 SYT6 TBC1D22B TCP10L TFIP11 TFPT TIMM44 TLE5 TMEM100 TNNI1 TP53BP2 TRIM14 TRIM29 TSEN54 TSGA10IP TSHZ2 TXLNA USP15 USP2 UTP14C VPS52 YJU2 ZBTB4 ZC2HC1C ZFC3H1 ZGPAT ZMAT2 ZNF417 ZNF436 ZNF474 ZNF552 ZNF648 ZNF655 ZNF688 ZNF835 ZSWIM3
Entrez ID		10252	284001
HPRD ID		06782	14150
Ensembl ID		ENSG00000164056	ENSG00000176155
Uniprot IDs		O43609	A0A590UJT6 Q2TAC2
PDB IDs
Enriched GO Terms of Interacting Partners?
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