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PRKAA2 and APPBP2
Data Source:
BioGRID
(two hybrid)
PRKAA2
APPBP2
Description
protein kinase AMP-activated catalytic subunit alpha 2
amyloid beta precursor protein binding protein 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Cytoplasmic Stress Granule
Nuclear Speck
Axon
Dendrite
Neuronal Cell Body
Nucleus
Nucleoplasm
Cytoplasm
Microtubule
Microtubule Associated Complex
Cytoplasmic Vesicle Membrane
Molecular Function
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Binding
ATP Binding
Histone Serine Kinase Activity
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
[acetyl-CoA Carboxylase] Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Microtubule Motor Activity
Protein Binding
Biological Process
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Cholesterol Biosynthetic Process
Carnitine Shuttle
Cell Cycle Arrest
Signal Transduction
Lipid Biosynthetic Process
Positive Regulation Of Autophagy
Negative Regulation Of Gene Expression
Response To Muscle Activity
Wnt Signaling Pathway
Macroautophagy
Positive Regulation Of Macroautophagy
Regulation Of Macroautophagy
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Cellular Response To Oxidative Stress
Histone-serine Phosphorylation
Intracellular Signal Transduction
Cellular Response To Drug
Cellular Response To Glucose Starvation
Regulation Of Fatty Acid Biosynthetic Process
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Positive Regulation Of Glycolytic Process
Rhythmic Process
Fatty Acid Homeostasis
Regulation Of Stress Granule Assembly
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Prostaglandin E Stimulus
Energy Homeostasis
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Cellular Protein Localization
Negative Regulation Of Tubulin Deacetylation
Positive Regulation Of Peptidyl-lysine Acetylation
Intracellular Protein Transport
Intracellular Transport
Pathways
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Lymphocyte counts (
22286170
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Waist-hip ratio (
28552196
)
Interacting Genes
122 interacting genes:
ABI1
ABI2
ACACA
ACACB
AIMP2
AKAP8L
AMOT
AMOTL2
ANAPC11
APPBP2
ARRDC3
AVPI1
C19orf47
CALCOCO1
CALCOCO2
CCDC172
CCDC33
CCNB1IP1
CDC42EP1
CDR2
CDX4
CPSF7
CTAG2
CYSRT1
DNAAF6
DNM2
DNMT1
DVL3
EEF2K
EMILIN1
EPM2A
EPN2
FNDC3B
FOS
GIGYF1
GLI1
GOLGA2
GOLGA6A
GRAP2
HAT1
HMBOX1
HNF4A
HOMEZ
IKZF1
IKZF3
KCTD1
KCTD9
KIAA1328
KIF16B
KIF24
KIFC3
KRT16
KRT31
KRTAP1-3
KRTAP10-3
KRTAP10-9
L3MBTL3
LCN2
LEP
LZTS2
MKRN3
MORN3
MRFAP1
MTUS2
MYCL
MYOZ1
NAB2
NECAB2
NONO
NOTCH2NLA
NRAP
NRBF2
NUTM1
PBXIP1
PFKFB2
PLEKHN1
PPP1R32
PRDM6
PRKAB1
PRKAG1
PRKAR1B
PRKN
PRPH
RASAL3
RBBP7
RBPMS
REL
RFX6
RPTOR
SERTAD3
SKIV2L
SLA2
SNW1
SOHLH1
SPRY1
STAC2
STK11
TCF4
TFAP2A
TIFA
TLE5
TMOD1
TRIP13
TRIP6
TSC22D4
UBE2I
USH1C
USH1G
USHBP1
USP10
VPS28
VPS37B
VPS52
WASHC1
WWP1
WWP2
YPEL3
ZBTB8A
ZMYND12
ZNF212
ZNF397
ZSCAN23
120 interacting genes:
-
AADAC
ACTN1
AHCY
AIM2
AK3
ALDH1L1
ANKRD10
APP
AR
ARMCX5
ATP13A1
BCL7A
BIN2
C1orf50
C6orf226
CALM3
CCDC167
CCDC85C
CCNL1
CDK16
CHMP5
CIBAR1
CLCN1
CNTFR
COL24A1
CORO2B
CREB3
CSNK1G2
CST2
CTC1
CYBA
DCD
DHRS2
DHX16
DOLK
DPEP1
DPYS
EID3
ERO1A
FAM107A
FSTL1
FXYD7
GALNT3
GCSAM
GP9
GPRC5C
GSTP1
H2AC15
HGFAC
HIPK4
HSD3B7
HSPA4
ITGB4
ITGB5
KHK
KIF6
KLF11
KLHL35
LANCL2
LONRF3
LUC7L2
LUZP4
MAN2B2
MCOLN1
MFSD3
MGAT4B
MLLT3
MMP28
MSH2
MSLN
MUL1
MYLK
NFYA
NPRL3
PCSK5
PI4KAP2
PNPLA5
PPIL6
PPP1R8
PRKAA2
PRKACB
PSAP
PTCH1
PYROXD2
RAB7B
RASSF5
RHEB
RILPL1
RNF128
RNF34
RNGTT
RRS1
SELENOI
SELENOV
SLC22A6
SLC25A23
SLC7A10
SLC9A3R1
SNX5
SPDYE2
SPDYE2B
ST8SIA5
SYNRG
SYT11
TAF11
TAFA4
TBL3
TCF25
TNP2
TRMT2A
UBE2R2
UGGT2
WAS
WDR24
WFIKKN1
WNT5B
ZC3H10
ZCCHC12
ZNF747
Entrez ID
5563
10513
HPRD ID
02735
05616
Ensembl ID
ENSG00000162409
ENSG00000062725
Uniprot IDs
P54646
A0A024QZ47
Q92624
PDB IDs
2H6D
2LTU
2YZA
3AQV
4CFE
4CFF
4ZHX
5EZV
5ISO
6B1U
6B2E
6BX6
Enriched GO Terms of Interacting Partners
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